Evidence map›Paper›PMID 33250896›Full record

ArticleFrontiers in immunology2020

Designs and Characterization of Subunit Ebola GP Vaccine Candidates: Implications for Immunogenicity.

Valentina Agnolon, Divor Kiseljak, Maria J Wurm, Florian M Wurm, Charlotte Foissard, Fabrice Gallais, Sarah Wehrle, César Muñoz-Fontela, Laurent Bellanger, Bruno Emanuel Correia and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Recent Advances in Therapeutic Approaches Against Ebola Virus Infection.Recent advances in anti-infective drug discovery · 2024
    Review
  4. Article
  5. Article
  6. Vaccines · 2023
    Article
  7. EnhancedJournal of virology · 2022
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Valentina AgnolonDivision of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Divor KiseljakExcellGene SA, Monthey, Switzerland.
Maria J WurmExcellGene SA, Monthey, Switzerland.
Florian M WurmExcellGene SA, Monthey, Switzerland.
Charlotte FoissardUniversité Paris Saclay, Commissariat à l'Energie Atomique et aux énergies alternatives (CEA), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAE), Département Médicaments et Technologies pour la Santé (DMTS), SPI, Bagnols-sur-Cèze, France.
Fabrice GallaisUniversité Paris Saclay, Commissariat à l'Energie Atomique et aux énergies alternatives (CEA), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAE), Département Médicaments et Technologies pour la Santé (DMTS), SPI, Bagnols-sur-Cèze, France.
Sarah WehrleLaboratory of Protein Design and Immunoengineering, École Polytechnique Fédérale De Lausanne (EPFL), Lausanne, Switzerland.
César Muñoz-FontelaBernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Laurent BellangerUniversité Paris Saclay, Commissariat à l'Energie Atomique et aux énergies alternatives (CEA), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAE), Département Médicaments et Technologies pour la Santé (DMTS), SPI, Bagnols-sur-Cèze, France.
Bruno Emanuel CorreiaLaboratory of Protein Design and Immunoengineering, École Polytechnique Fédérale De Lausanne (EPFL), Lausanne, Switzerland.
Giampietro CorradinDepartment of Biochemistry, Université de Lausanne (UNIL), Epalinges, Switzerland.
François SpertiniDivision of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
École Polytechnique Fédérale de Lausanne · CHUniversité Paris-Saclay · FRUniversity Hospital of Lausanne · CHGerman Center for Infection Research · DEInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement · FRUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The humoral responses of Ebola virus (EBOV) survivors mainly target the surface glycoprotein GP, and anti-GP neutralizing antibodies have been associated with protection against EBOV infection. In order to elicit protective neutralizing antibodies through vaccination a native-like conformation of the antigen is required. We therefore engineered and expressed in CHO cells several GP variants from EBOV (species

Indexed as

AnimalsAntibodies, NeutralizingAntibodies, ViralCHO CellsCricetulusEbola VaccinesHumansMiceVaccines, SubunitViral Envelope ProteinsAntibodies, NeutralizingAntibodies, ViralEbola Vaccinesenvelope glycoprotein, Ebola virusVaccines, SubunitViral Envelope ProteinsEbola glycoproteinEbola virusglycoproteinrecombinant vaccinetrimeric proteinvaccine

Identifiers

PMID33250896
PMCPMC7672190
OpenAlexW3097467831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.