Evidence map›Paper›PMID 33250893›Full record

ArticleFrontiers in immunology2020

Potential CD8+ T Cell Cross-Reactivity Against SARS-CoV-2 Conferred by Other Coronavirus Strains.

Chloe H Lee, Mariana Pereira Pinho, Paul R Buckley, Isaac B Woodhouse, Graham Ogg, Alison Simmons, Giorgio Napolitani, Hashem Koohy

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

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  14. De novo design of anti-variant COVID-19 vaccine.Biology methods & protocols · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Chloe H LeeMRC Human Immunology Unit, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Mariana Pereira PinhoMRC Human Immunology Unit, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Paul R BuckleyMRC Human Immunology Unit, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Isaac B WoodhouseMRC Human Immunology Unit, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Graham OggMRC Human Immunology Unit, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Alison SimmonsMRC Human Immunology Unit, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Giorgio NapolitaniMRC Human Immunology Unit, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Hashem KoohyMRC Human Immunology Unit, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Medical Research Council · GBMRC Human Immunology Unit · GBUniversity of Oxford · GBMRC Weatherall Institute of Molecular Medicine · GB

Funding

Medical Research Council G116/150Medical Research Council MC_PC_20002Medical Research Council MC_PC_MR/S025952/1Medical Research Council MC_U137881017Medical Research Council MC_UU_00008/5Medical Research Council MC_UU_00008/7Medical Research Council MC_UU_12010/5Medical Research Council MC_UU_12010/7Medical Research Council MR/S036377/1Wellcome Trust
6 · The paper itself

Abstract

While individuals infected with coronavirus disease 2019 (COVID-19) manifested a broad range in susceptibility and severity to the disease, the pre-existing immune memory to related pathogens cross-reactive against SARS-CoV-2 can influence the disease outcome in COVID-19. Here, we investigated the potential extent of T cell cross-reactivity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that can be conferred by other coronaviruses and influenza virus, and generated an

Indexed as

Cross ReactionsAmino Acid SequenceCD8-Positive T-LymphocytesComputer SimulationCoronavirusCOVID-19 VaccinesDatabases, FactualEpitopes, T-LymphocyteHumansOrthomyxoviridaeSARS-CoV-2COVID-19 VaccinesEpitopes, T-Lymphocyteantigen presentationCD8+ T cell recognitionCOVID-19cross-reactivityepitopespredict immunogenicitySARS-CoV-2

Identifiers

PMID33250893
PMCPMC7676914
OpenAlexW3094785443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.