ArticleFrontiers in physiology2020
Alpha-Arbutin Promotes Wound Healing by Lowering ROS and Upregulating Insulin/IGF-1 Pathway in Human Dermal Fibroblast.
Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Arbutin-A Hydroquinone Glycoside: Journey from Food Supplement to Cutting-Edge Medicine.Chinese journal of integrative medicine · 2026Review
- The In Vitro Wound-Scratch Assay: Applications, Technical Advances, and Limitations in Wound Healing Research.International wound journal · 2026Review
- Investigating the potential of Ulva rigida extracts as a natural anti-aging agent in cosmetics.Scientific reports · 2026Article
- A Comparative Single-Cell Atlas Reveals Pre-injury Signatures of Superior Healing in Oral Mucosa and Informing a New Paradigm for Wound Management.Functional & integrative genomics · 2026Article
- Biological Roles of Melanin and Natural Product-Derived Approaches for Its Modulation.International journal of molecular sciences · 2026Review
- Reactive oxygen species-dependent regulation of hypoxia-inducible factor 1α/C-X-C motif chemokine receptor 4 signaling promotes ozone-induced cancer metastasis.American journal of cancer research · 2026Article
- Cellular and molecular roles of reactive oxygen species in wound healing.Communications biology · 2024Review
- Electrospun PCL/gelatin/arbutin nanofiber membranes as potent reactive oxygen species scavengers to accelerate cutaneous wound healing.Regenerative biomaterials · 2024Article
- Assessment of in vitro anti-skin aging activities of Phyllanthus indofischeri Bennet extracts for dermatological and aesthetic applications.Scientific reports · 2023Article
- Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Turning gray selenium and sublimed sulfur into a nanocomposite to accelerate tissue regeneration by isothermal recrystallization.Journal of nanobiotechnology · 2023Article
- Biotransformation of hydroquinone into α-arbutin by transglucosylation activity of a metagenomic amylosucrase.3 Biotech · 2021Article
- Arbutin as a Skin Depigmenting Agent with Antimelanogenic and Antioxidant Properties.Antioxidants (Basel, Switzerland) · 2021Review
- Identification of potential hub genes associated with skin wound healing based on time course bioinformatic analyses.BMC surgery · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alpha-arbutin (4-hydroxyphenyl alpha-glucopyranoside) is a known inhibitor of tyrosinase in keratinocytes; however, its effect on other genes and pathways in other skin cells has not been thoroughly investigated. In this study, we investigate the mechanism of alpha-arbutin activity in human dermal fibroblast cultures for 48 h. Results showed that the oxidative stress pathway was activated as alpha-arbutin reduced reactive oxygen species. In addition, we found a high possibility of wound healing and the upregulation of the insulin-like growth factor 1 receptor (IFG1R) pathway. We also investigated the role of the NRF2 gene in mediating the alpha-arbutin response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.