ReviewJournal of perinatology : official journal of the California Perinatal Association2021
Practical approaches to sedation and analgesia in the newborn.
Review in Journal of perinatology : official journal of the California Perinatal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 105 citations in OpenAlex.
- Narrative Review of Nanomaterial Interactions in Plants with a Focus on Multi-Omics and Epigenetic Remodeling.Plants (Basel, Switzerland) · 2026Review
- Fentanyl Exposure Is Associated with Adverse Respiratory Outcomes in Ventilated Preterm Neonates: A Retrospective Matched Cohort Study.Journal of clinical medicine · 2026Article
- Analgosedation in Neonatal Intensive Care: Current Strategies, Challenges, and Future Perspectives.Life (Basel, Switzerland) · 2026Review
- Sedative use in infants with grade 3 bronchopulmonary dysplasia (BPD) and associations with neurodevelopmental therapies.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Tiny doses, big impact: Optimizing sedation weaning to reduce opioid use in a Level IV NICU.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Dexmedetomidine and midazolam usage and association with BSRI scores in preterm infants with chronic respiratory failure.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Analgesia and sedation trends in a level IV NICU, 2014-2024: Opioid and dexmedetomidine use.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Pharmacological therapy of neonatal analgosedation: current status, dilemmas, and perspectives.Frontiers in pediatrics · 2026Review
- Parental perception of pain in premature babies in neonatal intensive care unit: a qualitative study.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Managing pain in newborns: A multidimensional approach.Paediatrics & child health · 2025Review
- Pain management in preterm infants with necrotizing enterocolitis: an international expert consensus statement.European journal of pediatrics · 2025Article
- Neurodevelopmental outcomes at five years in children born very preterm (24-31 weeks) exposed to opioids with or without midazolam: results from the French nationwide EPIPAGE-2 cohort study.The Lancet regional health. Europe · 2025Article
- A global cross-sectional survey on neonatal analgosedation: unveiling global trends and challenges through latent class analysis.European journal of pediatrics · 2025Article
- Intranasal Analgesia in Preterm and Term Neonates.Paediatric drugs · 2025Review
- Research progress on multisensory stimulation therapy for pain during retinopathy of prematurity screening.Frontiers in pediatrics · 2025Review
- Neonatal intensive care nurses' assessment of preterm infants' pain and sedation: inter-rater reliability of the neonatal pain, agitation, and sedation scale.Frontiers in pediatrics · 2025Article
- Neonatal Pain Management: Is There An Endocrinal Response?Endocrine, metabolic & immune disorders drug targets · 2025Review
- Refractory agitation in the NICU: challenges in prevention, diagnosis, and treatment.Frontiers in pediatrics · 2025Article
- Detection of neurologic changes in critically ill infants using deep learning on video data: a retrospective single center cohort study.EClinicalMedicine · 2024Article
- Brain health in preterm infants: importance of early-life pain and analgesia exposure.Pediatric research · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The prevention, assessment, and treatment of neonatal pain and agitation continues to challenge clinicians and researchers. Substantial progress has been made in the past three decades, but numerous outstanding questions remain. In this setting, clinicians must establish safe and compassionate standardized practices that consider available efficacy data, long-term outcomes, and research gaps. Novel approaches with limited data must be carefully considered against historic standards of care with robust data suggesting limited benefit and clear adverse effects. This review summarizes available evidence while suggesting practical clinical approaches to pain assessment and avoidance, procedural analgesia, postoperative analgesia, sedation during mechanical ventilation and therapeutic hypothermia, and the issues of tolerance and withdrawal. Further research in all areas represents an urgent priority for optimal neonatal care. In the meantime, synthesis of available data offers clinicians challenging choices as they balance benefit and risk in vulnerable critically ill neonates.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.