Evidence map›Paper›PMID 33250219›Full record

ArticleUltrasound in medicine & biology2021

Treating Porcine Abscesses with Histotripsy: A Pilot Study.

Thomas J Matula, Yak-Nam Wang, Tatiana Khokhlova, Daniel F Leotta, John Kucewicz, Andrew A Brayman, Matthew Bruce, Adam D Maxwell, Brian E MacConaghy, Gilles Thomas and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2021
    Pooled it
  2. Review
  3. Article
  4. Histotripsy-Induced Bactericidal Activity Correlates to Size of Cavitation Cloud In Vitro.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024
    Article
  5. Histotripsy: A Method for Mechanical Tissue Ablation with Ultrasound.Annual review of biomedical engineering · 2024
    Review
  6. Article
  7. Review
  8. Article
  9. Enhancement of Boiling Histotripsy by Steering the Focus Axially During the Pulse Delivery.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023
    Article
  10. Review
  11. Clinical translation of abdominal histotripsy: a review of preclinical studies in large animal models.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023
    Review
  12. The histotripsy spectrum: differences and similarities in techniques and instrumentation.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Thomas J MatulaApplied Physics Laboratory, University of Washington, Seattle, Washington, USA. Electronic address: Matula@uw.edu.
Yak-Nam WangApplied Physics Laboratory, University of Washington, Seattle, Washington, USA.
Tatiana KhokhlovaDepartment of Gastroenterology, University of Washington, Seattle, Washington, USA.
Daniel F LeottaApplied Physics Laboratory, University of Washington, Seattle, Washington, USA.
John KucewiczApplied Physics Laboratory, University of Washington, Seattle, Washington, USA.
Andrew A BraymanApplied Physics Laboratory, University of Washington, Seattle, Washington, USA.
Matthew BruceApplied Physics Laboratory, University of Washington, Seattle, Washington, USA.
Adam D MaxwellDepartment of Urology, University of Washington, Seattle, Washington, USA.
Brian E MacConaghyApplied Physics Laboratory, University of Washington, Seattle, Washington, USA.
Gilles ThomasApplied Physics Laboratory, University of Washington, Seattle, Washington, USA.
Valery P ChernikovResearch Institute of Human Morphology, Laboratory of Cell Pathology, Moscow, Russia.
Sergey V BuravkovFaculty of Fundamental Medicine, M. V. Lomonosov Moscow State University, Moscow, Russia.
Vera A KhokhlovaApplied Physics Laboratory, University of Washington, Seattle, Washington, USA; Department of Acoustics, Physics Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
Keith RichmondBioDevelopment Associates, Stanwood, Washington, USA.
Keith ChanDepartment of Radiology, University of Washington, Seattle, Washington, USA.
Wayne MonskyDepartment of Radiology, University of Washington, Seattle, Washington, USA.
University of Washington Applied Physics Laboratory · USUniversity of Washington · USLomonosov Moscow State University · RUNeuroDevelopment Center · USResearch Institute of Human Morphology · RU

Funding

HIFU for Noninvasive Abscess TreatmentR01EB019365 · NIBIB · UNIVERSITY OF WASHINGTON · PI MATULA, THOMAS · 2015 to 2018
$2.6M
Histotripsy liquefaction of clinically significant hematomasR01GM122859 · NIGMS · UNIVERSITY OF WASHINGTON · PI KHOKHLOVA, TATIANA · 2017 to 2020
$1.2M
Noninvasive fragmentation of urinary calculi with focused ultrasound burstsK01DK104854 · NIDDK · UNIVERSITY OF WASHINGTON · PI MAXWELL, ADAM DOUGLAS · 2015 to 2019
$686k
NIBIB NIH HHS R01 EB019365NIDDK NIH HHS K01 DK104854NIGMS NIH HHS R01 GM122859
6 · The paper itself

Abstract

Infected abscesses are walled-off collections of pus and bacteria. They are a common sequela of complications in the setting of surgery, trauma, systemic infections and other disease states. Current treatment is typically limited to antibiotics with long-term catheter drainage, or surgical washout when inaccessible to percutaneous drainage or unresponsive to initial care efforts. Antibiotic resistance is also a growing concern. Although bacteria can develop drug resistance, they remain susceptible to thermal and mechanical damage. In particular, short pulses of focused ultrasound (i.e., histotripsy) generate mechanical damage through localized cavitation, representing a potential new paradigm for treating abscesses non-invasively, without the need for long-term catheterization and antibiotics. In this pilot study, boiling and cavitation histotripsy treatments were applied to subcutaneous and intramuscular abscesses developed in a novel porcine model. Ultrasound imaging was used to evaluate abscess maturity for treatment monitoring and assessment of post-treatment outcomes. Disinfection was quantified by counting bacteria colonies from samples aspirated before and after treatment. Histopathological evaluation of the abscesses was performed to identify changes resulting from histotripsy treatment and potential collateral damage. Cavitation histotripsy was more successful in reducing the bacterial load while having a smaller treatment volume compared with boiling histotripsy. The results of this pilot study suggest focused ultrasound may lead to a technology for in situ treatment of acoustically accessible abscesses.

Indexed as

High-Intensity Focused Ultrasound AblationUltrasonography, InterventionalAbscessAnimalsDisease Models, AnimalFemalePilot ProjectsSwineAbscessAcoustic bactericideBacteria inactivationFocused ultrasoundFocused UltrasoundHigh-intensity focused ultrasoundHistotripsyImage-Guided Therapy

Identifiers

PMID33250219
PMCPMC7855811
OpenAlexW3107613728

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.