Evidence map›Paper›PMID 33249982›Full record

ArticleAutophagy2021

Vacuolar processing enzyme translocates to the vacuole through the autophagy pathway to induce programmed cell death.

Paula Teper-Bamnolker, Raz Danieli, Hadas Peled-Zehavi, Eduard Belausov, Mohamad Abu-Abied, Tamar Avin-Wittenberg, Einat Sadot, Dani Eshel

Open access · bronzeAbstract read
In one paragraph

Article in Autophagy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Autophagy and Bacterial infections.Autophagy reports · 2025
    Review
  7. CSF2 polarized neutrophils and invaded renal cancer cellsOpen medicine (Warsaw, Poland) · 2025
    Article
  8. Review
  9. Article
  10. Autophagy in plants.Autophagy reports · 2024
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Vacuolar Processing Enzymes in Plant Programmed Cell Death and Autophagy.International journal of molecular sciences · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Paula Teper-BamnolkerDepartment of Postharvest Science, The Volcani Center, ARO, Rishon LeZion, Israel.
Raz DanieliDepartment of Postharvest Science, The Volcani Center, ARO, Rishon LeZion, Israel.
Hadas Peled-ZehaviDepartment of Plant and Environmental Sciences, The Weizmann Institute of Science, Rehovot Israel.ORCID 0000-0001-8169-5104
Eduard BelausovDepartment of Ornamental Horticulture, The Volcani Center, ARO, Rishon LeZion, Israel.
Mohamad Abu-AbiedDepartment of Ornamental Horticulture, The Volcani Center, ARO, Rishon LeZion, Israel.
Tamar Avin-WittenbergDepartment of Plant and Environmental Sciences, Alexander Silberman Institute of Life Sciences, the Hebrew University of Jerusalem, Givat Ram, Jerusalem, Israel.
Einat SadotDepartment of Ornamental Horticulture, The Volcani Center, ARO, Rishon LeZion, Israel.
Dani EshelDepartment of Postharvest Science, The Volcani Center, ARO, Rishon LeZion, Israel.
Agricultural Research Organization · ILHebrew University of Jerusalem · ILWeizmann Institute of Science · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The caspase-like vacuolar processing enzyme (VPE) is a key factor in programmed cell death (PCD) associated with plant stress responses. Growth medium lacking a carbon source and dark conditions caused punctate labeling of 35S::VPE1-GFP (StVPE1-GFP) in potato leaves. Under conditions of carbon starvation, VPE activity and PCD symptoms strongly increased in BY-2 cells, but to a much lesser extent in

Indexed as

AutophagyVacuolesApoptosisCysteine EndopeptidasesCysteine Endopeptidasesvacuolar processing enzymeAutophagosomeautophagy-related geneBY-2 cellscarbon starvationcaspase-like proteaseSolanum tuberosumtobacco

Identifiers

PMID33249982
PMCPMC8526000
OpenAlexW3109704886

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.