ArticleHypertension (Dallas, Tex. : 1979)2021
β-Arrestin-Biased Agonist Targeting the Brain AT
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Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- β-Arrestin-2 Regulates Sodium Taste Processing.Hypertension (Dallas, Tex. : 1979) · 2026Article
- A Pathophysiologic Mechanism for the Treatment of Salt-Sensitive Hypertension and Heart Failure: The Role of β-Arrestins.Clinical drug investigation · 2026Review
- Functional consequences of spatial, temporal and ligand bias of G protein-coupled receptors.Nature reviews. Nephrology · 2024Review
- Genetic Deletion of β-Arrestin 2 From the Subfornical Organ and Other Periventricular Nuclei in the Brain Alters Fluid Homeostasis and Blood Pressure.Hypertension (Dallas, Tex. : 1979) · 2024Article
- How New Developments in Pharmacology Receptor Theory Are Changing (Our Understanding of) Hypertension Therapy.American journal of hypertension · 2024Review
- Insights Into the Role of Angiotensin-II ATHypertension (Dallas, Tex. : 1979) · 2024Review
- β-Arrestin pathway activation by selective ATR1 agonism promotes calcium influx in podocytes, leading to glomerular damage.Clinical science (London, England : 1979) · 2023Article
- Interaction of Angiotensin II AT1 Receptors with Purinergic P2X Receptors in Regulating Renal Afferent Arterioles in Angiotensin II-Dependent Hypertension.International journal of molecular sciences · 2023Review
- Distinct Mechanisms of β-Arrestin-Biased Agonist and Blocker of AT1R in Preventing Aortic Aneurysm and Associated Mortality.Hypertension (Dallas, Tex. : 1979) · 2023Article
- ARRB2 (β-Arrestin-2) Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent on sodium and nonsodium components of diet.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Methods for the ComprehensiveFrontiers in physiology · 2022Article
- Defective Uteroplacental Vascular Remodeling in Preeclampsia: Key Molecular Factors Leading to Long Term Cardiovascular Disease.International journal of molecular sciences · 2021Review
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Authors and funding
9 authors at 3 institutions in 1 country.
Mario Zanaty *From the Department of Physiology, Cardiovascular Center Medical College of Wisconsin, Milwaukee, WI (M.Z., P.N., N.M.M., K.B., J.L.G., C.D.S.).
Fernando A C Seara *Department of Pharmacology and Neuroscience (F.A.C.S., G.D.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA.
Pablo Nakagawa *From the Department of Physiology, Cardiovascular Center Medical College of Wisconsin, Milwaukee, WI (M.Z., P.N., N.M.M., K.B., J.L.G., C.D.S.).
Guorui DengDepartment of Pharmacology and Neuroscience (F.A.C.S., G.D.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA.
Natalia M MathieuFrom the Department of Physiology, Cardiovascular Center Medical College of Wisconsin, Milwaukee, WI (M.Z., P.N., N.M.M., K.B., J.L.G., C.D.S.).
Kirthikaa BalapattabiFrom the Department of Physiology, Cardiovascular Center Medical College of Wisconsin, Milwaukee, WI (M.Z., P.N., N.M.M., K.B., J.L.G., C.D.S.).
Sadashiva S KarnikMolecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH (S.S.K.).
Justin L GrobeFrom the Department of Physiology, Cardiovascular Center Medical College of Wisconsin, Milwaukee, WI (M.Z., P.N., N.M.M., K.B., J.L.G., C.D.S.).
Curt D SigmundFrom the Department of Physiology, Cardiovascular Center Medical College of Wisconsin, Milwaukee, WI (M.Z., P.N., N.M.M., K.B., J.L.G., C.D.S.).
Medical College of Wisconsin · USUniversity of Iowa · USCleveland Clinic Lerner College of Medicine · US
Funding
Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2007 to 2022
$30.2MZONISMIDE IN THE TREATMENT OF SEIZURES IN PATIENTSM01RR000058 · NCRR · MEDICAL COLLEGE OF WISCONSIN · PI BROUSSEAU, DAVID C · 1985 to 2006
$19.9MINTERDISCIPLINARY CARDIOVASCULAR RESEARCH FELLOWSHIPT32HL007121 · NHLBI · UNIVERSITY OF IOWA · PI LONDON, BARRY · 1985 to 2020
$15.1MPPARG-dependent Mechanisms Control Endothelial-Smooth Muscle Coordination, Arterial Pressure, Vasomotor Function and Arterial StiffnessR35HL144807 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI SIGMUND, CURT DANIEL · 2019 to 2024
$5.5MInteraction between leptin and angiotensin in the pathogenesis of obesity-hypertensionR01HL134850 · NHLBI · UNIVERSITY OF IOWA · PI Justin L Grobe · 2017 to 2026
$4.4MTraining in Signature Transdisciplinary Cardiovascular SciencesT32HL134643 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Justin L Grobe, Jacquelyn P Kulinski · 2017 to 2026
$4.2MTraining Program in Hypertension, Kidney Disease & Cell BiologyT32DK007690 · NIDDK · UNIVERSITY OF IOWA · PI HUANG, CHOU-LONG, RAHMOUNI, KAMAL · 1992 to 2022
$2.8MModulation of Protective RAS-GPCR Pathways in Aortic DiseaseR01HL142091 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI KARNIK, SADASHIVA S · 2018 to 2021
$2.6MStructure-Guided Studied of GPCRs of RASR01HL132351 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI KARNIK, SADASHIVA S · 2017 to 2019
$1.6MRole of the prorenin receptor in blood pressure and autonomic control through the local activation of the renin angiotensin system in the brainstemK01HL153101 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI NAKAGAWA, PABLO · 2020 to 2024
$562kStructure-Guided Analysis of Mechanisms of AT1R FunctionsR56HL132351 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI KARNIK, SADASHIVA S · 2016 to 2016
$548kNCRR NIH HHS M01 RR000058NHLBI NIH HHS K01 HL153101NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R01 HL132351NHLBI NIH HHS R01 HL134850NHLBI NIH HHS R01 HL142091NHLBI NIH HHS R35 HL144807NHLBI NIH HHS R56 HL132351NHLBI NIH HHS T32 HL007121NHLBI NIH HHS T32 HL134643NIDDK NIH HHS T32 DK007690
Abstract
Activation of central AT
Indexed as
Angiotensin II Type 1 Receptor BlockersAnimalsbeta-ArrestinsBlood PressureCell LineChoice BehaviorDesoxycorticosteroneHypertensionLosartanMiceNeuronsOligopeptidesReceptor, Angiotensin, Type 1Renin-Angiotensin SystemAngiotensin II Type 1 Receptor Blockersbeta-ArrestinsDesoxycorticosteroneLosartanOligopeptidesReceptor, Angiotensin, Type 1Sar-Arg-Val-Tyr-Ile-His-Pro-Ala-OHangiotensin receptorbeta-arrestinblood pressuredrinking behaviorhypertensionrenin-angiotensin system
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.