Evidence map›Paper›PMID 33249860›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Progression of Beat-to-Beat Blood Pressure Variability Despite Best Medical Management.

Alastair J S Webb, Amy Lawson, Karolina Wartolowska, Sara Mazzucco, Peter M Rothwell

Open access · hybridAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Individuals with posttraumatic stress disorder have increased beat-to-beat blood pressure variability.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
  3. Article
  4. Prognostic value of beat-to-beat blood pressure variability parameters in patients after mechanical thrombectomy.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  5. Assessment of blood pressure variability: characteristics and comparison of blood pressure measurement methods.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Augmented resting beat-to-beat blood pressure variability in patients with chronic kidney disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023
    Article
  10. Article
  11. Short- to long-term blood pressure variability: Current evidence and new evaluations.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Blood pressure variability and target organ damage regression in hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Alastair J S WebbFrom the Wolfson Centre for Prevention of Stroke and Dementia, University of Oxford, United Kingdom.
Amy LawsonFrom the Wolfson Centre for Prevention of Stroke and Dementia, University of Oxford, United Kingdom.
Karolina WartolowskaFrom the Wolfson Centre for Prevention of Stroke and Dementia, University of Oxford, United Kingdom.
Sara MazzuccoFrom the Wolfson Centre for Prevention of Stroke and Dementia, University of Oxford, United Kingdom.
Peter M RothwellFrom the Wolfson Centre for Prevention of Stroke and Dementia, University of Oxford, United Kingdom.
Stroke Association · GB

Funding

British Heart Foundation PG/16/38/32080Department of HealthMedical Research Council G1000372Wellcome Trust 206589
6 · The paper itself

Abstract

Beat-to-beat variability in blood pressure (BP) is associated with recurrent stroke despite good control of hypertension. However, no study has identified rates of progression of beat-to-beat BP variability (BPV), its determinants, or which patient groups are particularly affected, limiting understanding of its potential as a treatment target. In consecutive patients one month after a transient ischaemic attack or nondisabling stroke (Oxford Vascular Study), continuous noninvasive BP was measured beat-to-beat over 5 minutes (Finometer). Arterial stiffness was measured by carotid-femoral pulse wave velocity (Sphygmocor). Repeat assessments were performed at the 5-year follow-up visit and agreement determined by intraclass correlation coefficient. Rates of progression of systolic BPV (SBPV) and diastolic BPV (DBPV) and their determinants were estimated by mixed-effect linear models, adjusted for age, sex, and cardiovascular risk factors. One hundred eighty-eight of 310 surviving, eligible patients had repeat assessments after a median of 5.8 years. Pulse wave velocity was highly reproducible but SBPV and DBPV were not (intraclass correlation coefficient: 0.71, 0.10, and 0.16, respectively), however, all 3 progressed significantly (pulse wave velocity, 2.39%,

Indexed as

AgedAge FactorsBlood PressureFemaleHumansHypertensionMaleMiddle AgedProspective StudiesPulse Wave AnalysisStrokeblood pressurehypertensionlinear modelsprognosisrisk factors

Identifiers

PMID33249860
PMCPMC7720874
OpenAlexW3108841781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.