ArticleJournal of clinical laboratory analysis2021
Ferritin as a key risk factor for nonalcoholic fatty liver disease in children with obesity.
Article in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Ferritin and Liver Steatosis in Children: Interactions Between Metabolic Clustering andInternational journal of molecular sciences · 2026Article
- Ferritin as an Inflammatory Marker in Pediatric Metabolic Syndrome: Links to Obesity and Liver Ultrasound Alterations.International journal of molecular sciences · 2025Article
- Article
- Associations of Ultrasound Findings with Serum Iron and Ferritin Levels in Children with Obesity.Life (Basel, Switzerland) · 2024Article
- Prolactin is a Key Factor for Nonalcoholic Fatty Liver Disease in Obese Children.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2023Article
- Analysis of risk factors for non-alcoholic fatty liver disease in hospitalized children with obesity before the late puberty stage.Frontiers in endocrinology · 2023Article
- Percent Body Fat-Related Disparities of Serum Ferritin on the Risk of Lipid Metabolism Abnormalities in Children and Adolescents.International journal of environmental research and public health · 2022Article
- The association between non-alcoholic fatty liver disease and serum ferritin levels in American adults.Journal of clinical laboratory analysis · 2022Article
- Ferritin as a key risk factor for nonalcoholic fatty liver disease in children with obesity.Journal of clinical laboratory analysis · 2021Article
- Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe association between serum ferritin and nonalcoholic fatty liver disease (NAFLD) in children with obesity is not clear. This study was designed to investigate whether serum ferritin can be an independent predictor for NAFLD.
methodsAccording to the hepatic ultrasound results, a total of 347 children with obesity were enrolled in this study. Among them, 95 patients with NAFLD and 95 without NAFLD were matched for gender, age, blood pressure and body mass index, the odds ratios (OR) and 95% confidence intervals (CI) for the association of ferritin and the risk of NAFLD were analyzed.
resultsAfter propensity score matching, ferritin values of the patients with NAFLD were significantly higher than those without NAFLD group. Alanine aminotransferase and ferritin were strongly associated with NAFLD in multivariate stepwise logistic regression analysis. The medium and high levels of ferritin increased risk of NAFLD, and the adjusted ORs were 3.298 (95% CI:1.326-8.204), 7.322 (95% CI:2.725-19.574) across the ferritin concentration tertiles after adjustment for confounders. Ferritin was shown to be the best predictor for NAFLD with sensitivity and specificity of 60.0% and 77.9%, respectively, area under the curve was 0.733.
conclusionThe results show that serum ferritin can usefully be considered as a predictor of NAFLD in children with obesity.
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