ReviewJournal of perinatology : official journal of the California Perinatal Association2021
The impact of maternal obesity on childhood neurodevelopment.
Review in Journal of perinatology : official journal of the California Perinatal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The impact of maternal vitamin D levels during pregnancy and risk of autism spectrum disorder and attention deficit hyperactivity disorder diagnosis and symptoms in offspring: a systematic review and dose-response meta-analysis.European child & adolescent psychiatry · 2026Pooled it
- A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows.Frontiers in neuroscience · 2021Pooled it
- Maternal Nutritional Status and Intrauterine Programming: Epigenetic Mechanisms and Their Impact on Offspring Health.Nutrients · 2026Review
- Maternal pre-pregnancy BMI and neurodevelopmental outcomes in children aged 18-36 months: a nationwide cohort study in Korea.Scientific reports · 2026Article
- Maternal pre-pregnancy body mass index, gestational weight gain and epilepsy in the offspring: A population-based cohort study.Epilepsy research · 2026Article
- Maternal Diabetes Mellitus and Child Neurodevelopmental Disorders: Rethinking Causality in Light of Environmental Pollutants.Journal of Korean medical science · 2026Review
- From Risks to Roots: The Multifactorial Etiopathogenesis of Childhood Obesity.International journal of molecular sciences · 2026Review
- Maternal obesity and inadequate gestational weight gain disrupts placental dopaminergic signaling: impact on infant neurodevelopment.Frontiers in endocrinology · 2026Article
- Dimethyl fumarate therapy in a Western diet pregnancy model: a pilot study in guinea pigs.PeerJ · 2026Article
- Neurodevelopmental Pathways from Maternal Obesity to Offspring Outcomes: An Umbrella Review of Cognitive and Behavioral Consequences Across Development.Healthcare (Basel, Switzerland) · 2025Review
- Maternal Overweight and Obesity Alter Neurodevelopmental Trajectories During the First Year of Life: Findings from the OBESO Cohort.Children (Basel, Switzerland) · 2025Article
- Maternal cardiovascular health and offspring neurodevelopment within the first five years of life: a birth cohort study.World journal of pediatrics : WJP · 2025Article
- Prenatal maternal HFD exposure impairs cognition via a hippocampal NMDA mechanism.Translational psychiatry · 2025Article
- Hypoxia in extravillous trophoblasts links maternal obesity and offspring neurobehavior.iScience · 2025Article
- Low glucose challenge test result as a potential risk factor for delays in early child development: the Japan environment and children's study.Journal of diabetes and metabolic disorders · 2025Article
- Fish Oil Supplementation Attenuates Offspring's Neurodevelopmental Changes Induced by a Maternal High-Fat Diet in a Rat Model.Nutrients · 2025Article
- Associations between maternal pre-pregnancy BMI and mean diffusivity of the hippocampus and amygdala in infants.International journal of obesity (2005) · 2025Article
- Impact of high maternal body mass index on fetal cerebral cortical and cerebellar volumes.Journal of perinatal medicine · 2025Article
- Maternal Obesity and Neurodevelopment of the Offspring.Nutrients · 2025Review
- Dynamic glycosylation remodeling in neurological disorders.Frontiers in molecular neuroscience · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is growing clinical and experimental evidence to suggest that maternal obesity increases children's susceptibility to neurodevelopmental and neuropsychiatric disorders. Given the worldwide obesity epidemic, it is crucial that we acquire a thorough understanding of the available evidence, identify gaps in knowledge, and develop an agenda for intervention. This review synthesizes human and animal studies investigating the association between maternal obesity and offspring brain health. It also highlights key mechanisms underlying these effects, including maternal and fetal inflammation, alterations to the microbiome, epigenetic modifications of neurotrophic genes, and impaired dopaminergic and serotonergic signaling. Lastly, this review highlights several proposed interventions and priorities for future investigation.
Indexed as
Identifiers
33249428What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.