Evidence map›Paper›PMID 33249373›Full record

ArticleJournal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)2021

Association between toenail zinc concentrations and incidence of asthma among American young adults: The CARDIA study.

Wenjing Tang, Pengcheng Xun, Cheng Chen, Liping Lu, Akshay Sood, James M Shikany, Ka Kahe

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Wenjing TangDepartment of Clinical Nutrition, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Nutrition, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Pengcheng XunDepartment of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA.
Cheng ChenDepartment of Obstetrics and Gynecology and Department of Epidemiology, Columbia University Irving Medical Center, New York, NY, USA.
Liping LuDepartment of Obstetrics and Gynecology and Department of Epidemiology, Columbia University Irving Medical Center, New York, NY, USA.
Akshay SoodHealth Sciences Center, School of Medicine, University of New Mexico, Albuquerque, NM, USA.
James M ShikanyDivision of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Ka KaheDepartment of Obstetrics and Gynecology and Department of Epidemiology, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: kk3399@columbia.edu.
Columbia University Irving Medical Center · USIndiana University Bloomington · USUniversity of Alabama at Birmingham · USUniversity of New Mexico · USXinHua Hospital · CN

Funding

Trace mineral levels, the trajectory of cognitive decline and telomere attritionRF1AG056111 · NIA · TRUSTEES OF INDIANA UNIVERSITY · PI KAHE, KA · 2017 to 2017
$3.1M
Trace mineral levels, metabolomics, and diabetes riskR01DK116603 · NIDDK · TRUSTEES OF INDIANA UNIVERSITY · PI KAHE, KA · 2018 to 2019
$1.5M
Trace Elements and CVD Risks Factors Among Young AdultsR01HL081572 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAHE, KA · 2006 to 2008
$1.2M
NHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS R01 HL081572NIA NIH HHS RF1 AG056111NIDDK NIH HHS R01 DK116603
6 · The paper itself

Abstract

backgroundAs an essential micronutrient, zinc plays an important role in modulating the immune system. However, data on the association between zinc concentrations and asthma incidence are sparse, especially in adults.

methodsWe prospectively followed up 3682 individuals aged 20-32 years without history of asthma or current asthma at baseline from 1987-1988 to 2015-2016. Zinc concentrations were measured in toenail clippings collected at Exam Year 2 using inductively-coupled-plasma mass spectroscopy. Asthma was diagnosed by a physician and/or reported medication use for asthma control with verification. Cox regression was used to model the association between toenail zinc concentrations and asthma incidence.

resultsOver an average of 22.5 years of follow-up, 508 incident cases of asthma were identified. After adjustment for potential confounders, no statistically significant association was found between zinc concentration and asthma incidence (HR = 0.81; 95% CI: 0.62, 1.07; P

conclusionsFindings from this prospective cohort study do not support a significant longitudinal association between toenail zinc concentrations and incidence of asthma among American young adults. Future studies are needed to confirm our findings.

Indexed as

AdolescentAdultAsthmaBlack or African AmericanCohort StudiesFemaleHumansMaleNailsProspective StudiesWhite PeopleYoung AdultZincZincAmerican young adultsAsthmaCARDIAProspective studyZinc

Identifiers

PMID33249373
PMCPMC7856182
OpenAlexW3098443793

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.