ArticleCancer epidemiology2021
Incidence of radiation induced sarcoma attributable to radiotherapy in adults: A retrospective cohort study in the SEER cancer registries across 17 primary tumor sites.
Article in Cancer epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Secondary Lower-Body Sarcomas in Cervical Cancer Survivors Following Surgery, Radiotherapy, or Both: A Population-Based Study.Cancer science · 2026Article
- Postoperative radiotherapy-induced pulmonary leiomyosarcoma in breast cancer: a case report and literature review.Frontiers in oncology · 2026Article
- Review
- A retrospective study of post-radiation sarcoma from three institutions in Japan with a review of the literature.Nagoya journal of medical science · 2025Article
- Rare Head and Neck Cancers and Pathological Diagnosis Challenges: A Comprehensive Literature Review.Diagnostics (Basel, Switzerland) · 2024Review
- Radiation-induced angiosarcoma-An unusual cause of recurrent pleural effusion.Respirology case reports · 2024Article
- A Review on Canine and Human Soft Tissue Sarcomas: New Insights on Prognosis Factors and Treatment Measures.Veterinary sciences · 2024Review
- Article
- Review
- Dose Volume and Liver Function Test Relationship following Radiotheraphy for Right Breast Cancer: A Multicenter Study.Current oncology (Toronto, Ont.) · 2023Article
- Cutaneous Radiation-Associated Angiosarcoma After Treatment of Carcinoma Penis: First Report from Tertiary Cancer Centre of North India.Indian journal of surgical oncology · 2023Article
- Genomic Profiling of Radiation-Induced Sarcomas Reveals the Immunologic Characteristics and Its Response to Immune Checkpoint Blockade.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023Article
- Sarcoma Predisposition in Dogs with a Comparative View to Human Orthologous Disease.Veterinary sciences · 2023Review
- Radiation-Induced Sarcomas of the Breast: A Review of a 20-Year Single-Center Experience.Cureus · 2023Article
- Incidence of radiation-associated sarcoma after breast-conserving surgery plus radiation.Journal of surgical oncology · 2023Article
- Risk of Secondary Cancer after Adjuvant Tamoxifen Treatment for Ductal Carcinoma In Situ: A Nationwide Cohort Study in South Korea.Diagnostics (Basel, Switzerland) · 2023Article
- Clinico-demographic characteristics and outcomes of radiation-induced sarcomas (RIS): a CanSaRCC study.Therapeutic advances in medical oncology · 2023Article
- Radiation-induced sarcomas: A single referral cancer center experience and literature review.Frontiers in oncology · 2022Article
- Deciphering miR-520c-3p as a probable target for immunometabolism in non-small cell lung cancer using systems biology approach.Oncotarget · 2022Article
- A Case Report of Post-RadiotherapyCase reports in oncologyArticle
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundPrevious studies have noted the incidence of radiation-induced sarcomas (RIS) but have not investigated the relative risk (RR) of developing RIS based on primary tumor organ disease site. By examining data from the Surveillance, Epidemiology, and End Results (SEER) database, we hypothesized that breast cancer would have a higher incidence of RIS compared to seventeen other primary cancer sites.
methodsThis was a retrospective cohort study that examined patients from SEER registries between 1973 and 2013. We included patients aged 18 years or older who were diagnosed with cancer and those diagnosed with a cancer who subsequently developed a sarcoma. We excluded patients with missing information on initial radiotherapy treatment or stage. RIS was defined as those who developed a secondary sarcoma near the site of their original malignancy and after a 24-month latency period.
resultsOur patients had a mean age of 60 years and follow up time of 9.2 years. Breast cancer comprised the majority with 693,701(36.8%) patients of which 161 (0.02%) had a secondary sarcoma. Of the 359 patients with secondary sarcomas, 242 (67.4%) had RIS. Breast cancer had the highest number of RIS patients at 126 compared to all combined non-breast cancer sites at 116. The RR of RIS in breast cancer versus 19 other primary cancer sites was 1.21 (CI: 1.01-1.45, p < 0.03, adjusted for age at primary diagnosis, gender, and latency).
conclusionsOur study demonstrated that breast cancer has a higher risk of developing RIS compared to other solid cancers.
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