ArticleProgress in neurobiology2021
Activation of endothelial Wnt/β-catenin signaling by protective astrocytes repairs BBB damage in ischemic stroke.
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Article in Progress in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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87citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
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Who cites it
87 citing papers in PubMed, 137 citations in OpenAlex.
- Role of the WNT signalling pathway in physiological and pathological blood-brain barrier.Annals of medicine · 2026Review
- Intermittent theta-burst stimulation promotes neurovascular unit remodeling after ischemic stroke in a mouse model.Neural regeneration research · 2026Article
- Total flavones of Rhododendron protect against BBB injury following cerebral ischemia/reperfusion via promoting astrocytic polarization towards A2 subtype.Apoptosis : an international journal on programmed cell death · 2026Article
- Microfluidic-mass spectrometry analysis of blood-brain barrier transport using engineered microparticle interfaces.Chemical science · 2026Article
- The rise of astrocytes: are they guardians or troublemakers of the brain disorder?Experimental & molecular medicine · 2026Review
- Neuroprotective Mechanisms of Hyperbaric Oxygen Therapy in Cerebral Ischemia-Hypoxia Injury Following Cardiopulmonary Resuscitation.International journal of medical sciences · 2026Review
- Salidroside targets the Notch1/Hes5 axis to reconstruct the molecular innate immune-vascular network and correlates with repair after ischemic stroke.Frontiers in immunology · 2026Article
- METTL16 Promotes Cerebral Ischemia-Reperfusion Injury via mInternational journal of general medicine · 2026Article
- A systematic review of the cerebrovascular adaptations following exposure to spaceflight or ground-based analogs: lessons from human and animal studies.NPJ microgravity · 2025Article
- Selective Deletion of NBCe1 in Reactive Astrocytes Attenuates Ischemic Stroke Brain Damage.Glia · 2025Article
- Progression and Metastasis of Lung Cancer: Clinical Features, Molecular Mechanisms, and Clinical Managements.MedComm · 2025Review
- Across Barriers: Blood-Brain and Gut Barrier Signaling in Psychiatric Disorders.Journal of neurochemistry · 2025Review
- SARS-CoV-2 Infection Influences Wnt/β-Catenin Pathway Components in Astrocytes.Pathogens (Basel, Switzerland) · 2025Article
- Irisin/FNDC5 Regulates Endothelial Function to Improve Post-Stroke-Induced Cognitive Dysfunction by Stimulating AMPK-eNOS Signaling.Brain and behavior · 2025Article
- Activity and Heterogeneity of Astrocytes in Neurological Diseases: Molecular Mechanisms and Therapeutic Targets.MedComm · 2025Review
- Tirzepatide mitigates Stroke-Induced Blood-Brain barrier disruption by modulating Claudin-1 and C/EBP-α pathways.Molecular medicine (Cambridge, Mass.) · 2025Article
- Potential Biological and Genetic Links Between Dementia and Osteoporosis: A Scoping Review.Geriatrics (Basel, Switzerland) · 2025Review
- Exploring Recent Developments in the Manifestation, Diagnosis, and Treatment of Patients with Smith-Lemli-Opitz Syndrome: From Molecular Pathways to Clinical Innovations.International journal of molecular sciences · 2025Review
- Cerebral Perfusion Characteristics and Dynamic Brain Structural Changes in Stroke-Prone Renovascular Hypertensive Rats: A Preclinical Model for Cerebral Small Vessel Disease.Translational stroke research · 2025Article
- The Role of Astrocytes in Poststroke Rehabilitation.Brain and behavior · 2025Review
27 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Shanshan SongDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; The Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, USA.
Huachen HuangDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Xiudong GuanDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Victoria FieslerDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; The Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, USA.
Mohammad Iqbal H BhuiyanDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; The Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, USA.
Ruijia LiuDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Shayan JalaliDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Md Nabiul HasanDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; The Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, USA.
Albert K TaiDepartment of Immunology, Tufts University, Boston, MA, USA.
Ansuman ChattopadhyayMolecular Biology-Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, PA, USA.
Srilakshmi ChaparalaMolecular Biology-Information Service, Health Sciences Library System, University of Pittsburgh, Pittsburgh, PA, USA.
Ming SunDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Donna B StolzDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Pingnian HeDepartment of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine, Hershey, PA, USA.
Dritan AgalliuDepartments of Neurology, Pathology & Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
Dandan SunDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; The Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, USA; Veterans Affairs Pittsburgh Health Care System, Geriatric Research, Educational and Clinical Center, Pittsburgh, PA, USA.
Gulnaz BegumDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; The Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: gub6@pitt.edu.
University of Pittsburgh · USColumbia University Irving Medical Center · USPennsylvania State University · USTufts University · US
Funding
The Role of Na+/H+ exchanger in Cerebral IschemiaR01NS048216 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Dandan Sun · 2005 to 2026
$6.1MRed blood cell released ATP in disturbed blood flow-initiated site specific vascular inflammation and atherosclerosisR01HL144620 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HE, PINGNIAN · 2019 to 2022
$3.1MNitric oxide and microvessel permeability in vivoR01HL130363 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HE, PINGNIAN · 2017 to 2020
$1.9MAstrocytes-Mediated Regulation of Wnt/b-Catenin Pathway in Ischemic BrainR01NS110755 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BEGUM, GULNAZ · 2020 to 2024
$1.7MDeveloping a microfluidic human neurovascular unit system to investigate genetic and age-related risk factors in Alzheimer's diseaseR01AG078352 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Dritan Agalliu, Andrew Alexander Sproul · 2025 to 2026
$837kRequest for transmission electron microscope for the University of PittsburghS10OD016236 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WATKINS, SIMON C · 2013 to 2013
$459kNHLBI NIH HHS R01 HL130363NHLBI NIH HHS R01 HL144620NIA NIH HHS R01 AG078352NIH HHS S10 OD016236NINDS NIH HHS R01 NS048216NINDS NIH HHS R01 NS110755
Abstract
The role of astrocytes in dysregulation of blood-brain barrier (BBB) function following ischemic stroke is not well understood. Here, we investigate the effects of restoring the repair properties of astrocytes on the BBB after ischemic stroke. Mice deficient for NHE1, a pH-sensitive Na
Indexed as
Blood-Brain BarrierBrain IschemiaIschemic StrokeAnimalsAstrocytesbeta CateninMiceWnt Signaling Pathwaybeta CateninCTNNB1 protein, mouseAngiogenesisAstrocytesBlood-Brain barrierNa(+)/H(+)exchanger isoform-1Wnt/β-catenin signaling
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.