ArticlePoultry science2020
Highly nutritious diet resists Salmonella Typhimurium infections by improving intestinal microbiota and morphology in broiler chickens.
Article in Poultry science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- Gut microbiota signatures associated with the development of Salmonella Typhimurium super-shedders in broiler chickens.Poultry science · 2026Article
- Protective Effect of Synbiotic Supplementation AgainstAnimals : an open access journal from MDPI · 2026Article
- Gut commensal Parabacteroides goldsteinii protects against Salmonella infection in mice by enhancing innate defense function.NPJ biofilms and microbiomes · 2026Article
- Effects of dietary β-mannanase supplementation in low-energy and low-protein diets containing high-mannan ingredients on growth performance, meat quality, intestinal morphology, and liver health in broiler chickens.Animal bioscience · 2026Article
- Co-inoculation of broilers byMicrobiology spectrum · 2026Article
- Dose-dependent contribution of Eimeria tenella to Salmonella infection in broilers: impacts on growth, immunity, and cecal microbiota.Poultry science · 2025Article
- Effect of β-mannanase supplementation in low-energy and lowprotein diets on performance, intestinal morphology, and fatty liver incidence in laying hens.Animal bioscience · 2025Article
- Immune stress impairs broiler performance by affecting hypothalamic methylation modification and intestinal 5-HT synthesis.Poultry science · 2025Article
- The Interactive Effects of Nutrient Density and Breed on Growth Performance and Gut Microbiota in Broilers.Animals : an open access journal from MDPI · 2024Article
- Effect of increasing β-mannanase supplementation in diets containing copra meal on growth performance, meat quality, liver health, intestinal morphology, and nutrient utilization in broiler chickens.Animal bioscience · 2024Article
- Effects ofAnimals : an open access journal from MDPI · 2023Article
- Phenotype Alterations in the Cecal Ecosystem Involved in the Asymptomatic Intestinal Persistence of ParatyphoidAnimals : an open access journal from MDPI · 2023Review
- Negative consequences of reduced protein diets supplemented with synthetic amino acids for performance, intestinal barrier function, and caecal microbiota composition of broiler chickens.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- DietaryAnimals : an open access journal from MDPI · 2023Article
- Shifts in intestinal microbiota and improvement of sheep immune response to resist Salmonella infection using Toll-like receptor 4 (TLR4) overexpression.Frontiers in microbiology · 2023Article
- Effect ofAnimals : an open access journal from MDPI · 2022Article
- Article
- Effects of Lysophosphatidylcholine on Jejuna Morphology and Its Potential Mechanism.Frontiers in veterinary science · 2022Article
- Non-Antibiotics Strategies to ControlAnimals : an open access journal from MDPI · 2022Review
- Assessment ofAnimals : an open access journal from MDPI · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salmonella Typhimurium (S. Typhimurium) infection in broiler chickens threatens public health and livestock production. In this study, we explored the effects of highly nutritious (crude protein 21.8%, metabolizable energy 3.16 Mcal/kg) and lowly nutritious (crude protein 18.1%, metabolizable energy 2.98 Mcal/kg) diets on S. Typhimurium infection by altering the intestinal morphology and environment in broiler chickens. The highly nutritious diet significantly increased the body weight gain and reduced feed conversion ratio on day 1 to 21 (P < 0.01). The highly nutritious diets promoted the intestinal villus height, crypt depth, and their ratio to improve the intestinal epithelial maturation (P < 0.05). Highly nutritious diets significantly increased the expression of claudin-1, occludin, and NF-κB genes in the intestinal epithelium on the days of 14 and 21 (P < 0.05). S. Typhimurium activated the expression of TLR4, MyD88, and NF-κB genes to cause an inflammatory response. The S. Typhimurium can increase the activity of myeloperoxidase, which cause an inflammatory response. The S. Typhimurium significantly reduced the diversity indexes of the ileal microbiota (P < 0.05), increased the abundance of Cyanobacteria which can synthesize toxins. The highly nutritious diet group challenged with S. Typhimurium can increase the abundance of Lactobacillus in the ileum, which lead to improved intestinal health (P < 0.05). It is concluded that increasing the nutritional level of dietary is beneficial to improve the resistance to S. Typhimurium infection by altering the intestinal bacterial community.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.