ArticlePoultry science2020
Evaluation of the efficacy of chlorogenic acid in reducing small intestine injury, oxidative stress, and inflammation in chickens challenged with Clostridium perfringens type A.
Article in Poultry science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 70 citations in OpenAlex.
- Effects of a Phytogenic Water Supplement on Selected Cultivable Bacterial Populations and Intestinal Histomorphology in Ross 308 Broiler Chickens Challenged withLife (Basel, Switzerland) · 2026Article
- A mugwort-based Chinese herbal mixture of five herbs improved oviduct health in laying hens under LPS challenge.Poultry science · 2026Article
- Synergistic effects of dietary RISCO-NUTRIFOUR probiotic on broiler performance, upregulation of intestinal immunoglobulin A and mucin-2 genes, enhancement of occludin expression, and downregulation of HSP70 under heat stress.Frontiers in veterinary science · 2026Article
- DietaryFrontiers in veterinary science · 2026Article
- Lactobacillus reuteri postbiotics improved growth performance and intestinal health of broilers with necrotic enteritis.BMC veterinary research · 2025Article
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- The impact of in ovo injection of cluster bean peptide on hatchability, growth performance, carcass characteristics, digestive enzymes, and blood indices of broiler chickens.BMC veterinary research · 2025Article
- The effects of Astragalus, Epimedium, and Fructus Ligustri Lucidi extract on the antioxidant capacity, and immune status of goslings under stress conditions.Frontiers in veterinary science · 2025Article
- Isochlorogenic acid derived from stevia improves antioxidant capacity, immune function and intestinal microbiota in weaned piglets.Frontiers in veterinary science · 2025Article
- Comparative Efficacy of Plant Extracts and Probiotics on Growth and Gut Health in Chickens with Necrotic Enteritis.Animals : an open access journal from MDPI · 2024Article
- Effects of DietaryAntioxidants (Basel, Switzerland) · 2024Article
- Chlorogenic acid ameliorates intestinal inflammation by inhibiting NF-κB and endoplasmic reticulum stress in lipopolysaccharide-challenged broilers.Poultry science · 2024Article
- Effect of Tannic Acid on Antioxidant Function, Immunity, and Intestinal Barrier of Broilers Co-Infected with Coccidia andAnimals : an open access journal from MDPI · 2024Article
- Dihydromyricetin improves growth performance, immunity, and intestinal functions in weaned pigs challenged by enterotoxigenicFrontiers in veterinary science · 2024Article
- Integrated multi-omics reveals the beneficial role of chlorogenic acid in improving the growth performance and immune function of immunologically stressed broilers.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- New Insights of Biological Functions of Natural Polyphenols in Inflammatory Intestinal Diseases.International journal of molecular sciences · 2023Review
- Dietary Supplementation with Chlorogenic Acid Enhances Antioxidant Capacity, Which Promotes Growth, Jejunum Barrier Function, and Cecum Microbiota in Broilers under High Stocking Density Stress.Animals : an open access journal from MDPI · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The goal of the study was testing the effects of chlorogenic acid (CA) supplementation on small intestine healthiness, growth performance, oxidative stress, inflammatory response, and blood biochemical indices in specific-pathogen-free (SPF) chickens after infection with Clostridium perfringens (CP) type A. In this study, 324 1-day-old male SPF chickens were randomly distributed into 6 groups: control group; CA group; CP infection group; CA + CP group; antibiotic group; antibiotic + CP group. All 1-day-old chickens were fed with CA or antibiotic in corresponding treatment group for 13 d. On the 14 d, the chickens in corresponding infection group were challenged with CP type A for 3 d. Samples in each group were collected when the chickens were 17 and 21 d old. This study proves for the first time that CA, a Chinese herbal medicine, can effectively improve growth performance, inhibit small intestine structural damage, improve antioxidant capacity, inhibit damage to ileal mucosal layer construction and tight junctions, inhibit inflammatory cytokines, and ameliorate blood biochemical indices. Therefore, this study provides data for CA being able to effectively alleviate small intestine damage caused by CP type A infection in chickens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.