Evidence map›Paper›PMID 33248536›Full record

ReviewJournal de medecine vasculaire2020

How to screen and diagnose deep venous thrombosis (DVT) in patients hospitalized for or suspected of COVID-19 infection, outside the intensive care units.

M Sebuhyan, R Mirailles, B Crichi, C Frere, P Bonnin, A Bergeron-Lafaurie, B Denis, G Liegeon, O Peyrony, D Farge and 1 more

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Journal de medecine vasculaire, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05028244 (Systematic Ultrasound Screening for Lower Extremity Deep Vein Thrombosis in ICU Patients With Severe COVID-19), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05028244 nacompletednot on this mapstarted 2021, after this paper: background citation

Systematic Ultrasound Screening for Lower Extremity Deep Vein Thrombosis in ICU Patients With Severe COVID-19: a Randomized Clinical Trial.

TypeinterventionalSponsorHospital Universitari Vall d'Hebron Research InstituteRan2021 to 2021Enrolled168ConditionsDeep Vein Thrombosis, Covid19, COVID-19 Pneumonia, COVID-19 Respiratory InfectionArmsvenous ultrasound of lower extremity
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

M SebuhyanUnité de médecine interne : maladies auto-immunes et pathologie vasculaire (UF04), hôpital Saint-Louis, Assistance publique-Hôpitaux de Paris (AP-HP), 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address: maxime.sebuhyan@aphp.fr.
R MiraillesUnité de médecine interne : maladies auto-immunes et pathologie vasculaire (UF04), hôpital Saint-Louis, Assistance publique-Hôpitaux de Paris (AP-HP), 1, avenue Claude-Vellefaux, 75010 Paris, France.
B CrichiUnité de médecine interne : maladies auto-immunes et pathologie vasculaire (UF04), hôpital Saint-Louis, Assistance publique-Hôpitaux de Paris (AP-HP), 1, avenue Claude-Vellefaux, 75010 Paris, France.
C FrereInserm UMRS_1166, service d'hématologie biologique, Sorbonne université, hôpital Pitié-Salpêtrière, Assistance publique-Hôpitaux de Paris (AP-HP), 47-83, boulevard de l'Hôpital, 75013 Paris, France.
P BonninService de physiologie clinique et explorations fonctionnelles, hôpital Lariboisière, Assistance publique-Hôpitaux de Paris (AP-HP), Paris, France.
A Bergeron-LafaurieService de pneumologie, hôpital Saint-Louis, Assistance publique-hôpitaux de Paris (AP-HP), 1, avenue Claude-Vellefaux, 75010 Paris, France.
B DenisService de maladie infectieuse, hôpital Saint-Louis, Assistance publique-Hôpitaux de Paris (AP-HP), 1, avenue Claude-Vellefaux, 75010 Paris, France.
G LiegeonService de maladie infectieuse, hôpital Saint-Louis, Assistance publique-Hôpitaux de Paris (AP-HP), 1, avenue Claude-Vellefaux, 75010 Paris, France.
O PeyronyService des urgences, hôpital Saint-Louis, Assistance publique-Hôpitaux de Paris (AP-HP), 1, avenue Claude-Vellefaux, 75010 Paris, France.
D FargeUnité de médecine interne : maladies auto-immunes et pathologie vasculaire (UF04), hôpital Saint-Louis, Assistance publique-Hôpitaux de Paris (AP-HP), 1, avenue Claude-Vellefaux, 75010 Paris, France; IRSL, EA-3518, recherche clinique appliquée à l'hématologie, université de Paris, 75010 Paris, France; Department of medicine, McGill university, Montreal, QC, Canada. Electronic address: dominique.farge-bancel@aphp.fr.
Saint-Louis CORE (COVID-19 RESEARCH) group
Hôpital Saint-Louis · FRHôpital Lariboisière · FRMcGill University · CASorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe Coronavirus disease-2019 outbreak (COVID-19) has been declared a pandemic by the World Health Organization. Studies report both a severe inflammatory syndrome and a procoagulant state in severe COVID-19 cases, with an increase of venous thromboembolism, including pulmonary embolism (PE) and deep vein thrombosis (DVT). In this context, we discuss the use of doppler ultrasonography (DUS) in the screening and diagnosis of DVT in ambulatory and hospitalized patients with, or suspected of having, COVID-19, outside the intensive care unit (ICU). MATERIAL AND

methodsNon-systematic review of the literature.

resultsIn patients hospitalized for or suspected of COVID-19 infection with the presence of either (a) DVT clinical symptoms, (b) a strong DVT clinical probability (Wells score>2) or (c) elevated D-dimer levels without DVT clinical symptoms and without PE on lung CT angio-scan, DVT should be investigated with DUS. In the presence of PE diagnosed clinically and/or radiologically, additional systematic DVT screening using DUS is not recommended during the COVID-19 pandemic. The use of 4-points compression DUS for DVT screen and diagnosis is the most appropriate method in this context. DISCUSSION: Systematic DUS for DVT screening in asymptomatic COVID patients is not recommended unless the patient is in the ICU. This would increase the risk of unnecessarily exposing medical staff to SARS-CoV-2 and monopolizing limited resources during this period.

Indexed as

HospitalizationUltrasonography, DopplerBiomarkersClinical Decision-MakingCOVID-19Fibrin Fibrinogen Degradation ProductsHumansIncidencePredictive Value of TestsRisk FactorsVenous ThrombosisBiomarkersFibrin Fibrinogen Degradation Productsfibrin fragment DCOVID-19 associated coagulopathyCOVID-19 pandemicDoppler ultrasoundFour-points compression ultrasoundPulmonary embolismVenous thromboembolismWells score

Identifiers

PMID33248536
PMCPMC7473249
OpenAlexW3082331095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.