Evidence map›Paper›PMID 33248456›Full record

ArticleJournal of biomedical science2020

MicroRNA-146a suppresses tumor malignancy via targeting vimentin in esophageal squamous cell carcinoma cells with lower fibronectin membrane assembly.

Hong-Yi Chang, Chi-Hua Lee, Yi-Syuan Li, Jing-Tong Huang, Sheng-Hui Lan, Yi-Fang Wang, Wu-Wei Lai, Yi-Ching Wang, Yan-Ju Lin, Hsiao-Sheng Liu and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Journal of biomedical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Hsa_circRNA_0101125 Promotes Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma via miR-143-3p/ZNF148 Axis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Hong-Yi ChangDepartment of Biotechnology and Food Technology, College of Engineering, Southern Taiwan University of Science and Technology, Tainan, Taiwan.
Chi-Hua LeeDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yi-Syuan LiInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Jing-Tong HuangInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Sheng-Hui LanDepartment of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan.
Yi-Fang WangDepartment of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wu-Wei LaiDivision of Thoracic Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yi-Ching WangInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yan-Ju LinBiomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan.
Hsiao-Sheng LiuDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. a713@mail.ncku.edu.tw.
Hung-Chi ChengInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan. hungchi@mail.ncku.edu.tw.
National Cheng Kung University · TWIndustrial Technology Research Institute · TWNational Cheng Kung University Hospital · TWNational Yang Ming Chiao Tung University · TWSouthern Taiwan University of Science and Technology · TW

Funding

Kaohsiung Medical University Research Center KMU-TC108A04-0 and KMU-TC108A04-2Ministry of Science and Technology, Taiwan MOST-104-2320-B-006-021-MY3Ministry of Science and Technology, Taiwan MOST-106-2320-B-006-068-MY3Ministry of Science and Technology, Taiwan MOST-109-2320-B-006-022-
6 · The paper itself

Abstract

backgroundEsophageal squamous cell carcinoma (ESCC) is widely prevalent in Taiwan, and high metastatic spread of ESCC leads to poor survival rate. Fibronectin (FN) assembly on the cell membrane may induce ESCC mobility. MicroRNAs (MiRNAs) are abundant in and participate in tumorigenesis in many cancers. However, the role of MiRNA in FN assembly-related ESCC mobility remains unexplored.

methodsWe divided ESCC CE81T cells into high-FN assembly (CE81

resultsCell proliferation and migration were decreased when CE81

conclusionsThis is the first report to link FN assembly in the cell membrane with miR-146a, vimentin and ESCC tumorigenesis both in vitro and in ESCC patients.

Indexed as

AdultAgedAged, 80 and overCell Line, TumorCell MembraneCell MovementCell ProliferationEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaFemaleFibronectinsHumansMaleMicroRNAsMiddle AgedVimentinFibronectinsFN1 protein, humanMicroRNAsMIRN146 microRNA, humanVimentinVIM protein, humanCell migrationESCCInvasionmiR-146aVimentin

Identifiers

PMID33248456
PMCPMC7697386
OpenAlexW3109698851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.