ArticleNeuroImage2021
Impact of concatenating fMRI data on reliability for functional connectomics.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed.
- Reversible modulation of a deep white matter surgical target for depression with low-intensity focused ultrasound.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Temporal stability of functional network configurations and its relationship to cognition and psychopathology in early psychoses.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- A neural signature of sleep deprivation in the human brain.Nature communications · 2026Article
- Increasing the Reliability of Functional Connectivity by Predicting Long-Scan Functional Connectivity based on Short-Scan Functional Connectivity: Model Exploration, Explanation, Validation, and Application.Neuroinformatics · 2026Article
- Cognition, but not affect, rests upon a segregated intrinsic network architecture.bioRxiv : the preprint server for biology · 2026Article
- Maximum entropy model reveals frequent brain state switching in a multiversal brain function analysis in early psychoses.bioRxiv : the preprint server for biology · 2026Article
- Large scale functional and effective connectivity alterations cross the Huntington's disease integrated staging system.NeuroImage. Clinical · 2026Article
- Connectome-based symptom mapping and in silico related gene expression in children with autism and/or attention-deficit/hyperactivity disorder.Molecular psychiatry · 2026Article
- Network homeostasis: functional brain network alterations and relapse in remitted late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Detailed Mapping of the Cerebellar Dentate Nucleus Using Ultra-High Field (7T) Susceptibility-Weighted Imaging.Cerebellum (London, England) · 2025Article
- Functional divergence between the two cerebral hemispheres contributes to human fluid intelligence.Communications biology · 2025Article
- Multimodal gradients unify local and global cortical organization.Nature communications · 2025Article
- Review
- How much is "enough"? Considerations for functional connectivity reliability in pediatric naturalistic fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Temporal variability of brain-behavior relationships in fine-scale dynamics of edge time series.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Is Pearson's correlation coefficient enough for functional connectivity in fMRI?Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Challenges in measuring individual differences of brain function.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Jointly estimating individual and group networks from fMRI data.Network neuroscience (Cambridge, Mass.) · 2025Article
- Excluding spontaneous thought periods enhances functional connectivity test-retest reliability and machine learning performance in fMRI.Frontiers in neuroscience · 2025Article
- Patterns of Change in Functional Connectivity and Motor Performance Are Different in Youth Recently Recovered from Concussion.Neurotrauma reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Compelling evidence suggests the need for more data per individual to reliably map the functional organization of the human connectome. As the notion that 'more data is better' emerges as a golden rule for functional connectomics, researchers find themselves grappling with the challenges of how to obtain the desired amounts of data per participant in a practical manner, particularly for retrospective data aggregation. Increasingly, the aggregation of data across all fMRI scans available for an individual is being viewed as a solution, regardless of scan condition (e.g., rest, task, movie). A number of open questions exist regarding the aggregation process and the impact of different decisions on the reliability of resultant aggregate data. We leveraged the availability of highly sampled test-retest datasets to systematically examine the impact of data aggregation strategies on the reliability of cortical functional connectomics. Specifically, we compared functional connectivity estimates derived after concatenating from: 1) multiple scans under the same state, 2) multiple scans under different states (i.e. hybrid or general functional connectivity), and 3) subsets of one long scan. We also varied connectivity processing (i.e. global signal regression, ICA-FIX, and task regression) and estimation procedures. When the total number of time points is equal, and the scan state held constant, concatenating multiple shorter scans had a clear advantage over a single long scan. However, this was not necessarily true when concatenating across different fMRI states (i.e. task conditions), where the reliability from the aggregate data varied across states. Concatenating fewer numbers of states that are more reliable tends to yield higher reliability. Our findings provide an overview of multiple dependencies of data concatenation that should be considered to optimize reliability in analysis of functional connectivity data.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.