ArticleBiophysical journal2021
Kinetic Membrane Model of Outer Hair Cells.
Article in Biophysical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Effectiveness of outer hair cells as cochlear amplifier: In simple model systems.Biophysical journal · 2025Article
- Of mice and chickens: Revisiting the RC time constant problem.Hearing research · 2022Review
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1 author.
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Abstract
The effectiveness of outer hair cells (OHCs) in amplifying the motion of the organ of Corti, and thereby contributing to the sensitivity of mammalian hearing, depends on the mechanical power output of these cells. Electromechanical coupling in OHCs, which enables these cells to convert electrical energy into mechanical energy, has been analyzed in detail using isolated cells using primarily static membrane models. The mechanical output of OHCs was previously evaluated by developing a kinetic theory based on a simplified one-dimensional model for OHCs. Here, a kinetic description of OHCs is extended by using the membrane model, which was used for analyzing in vitro experiments. This theory predicts, for systems without inertial load, that elastic load enhances positive shift of voltage dependence of the membrane capacitance because of turgor pressure. The effect of turgor pressure increases with increasing elastic load. For systems with inertia, the magnitude of mechanical power output could be ∼5% higher than the value predicted by the one-dimensional model at the optimal turgor pressure.
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