Evidence map›Paper›PMID 33248069›Full record

ArticleExperimental eye research2021

Morphometric analysis of the lens in human aniridia and mouse Small eye.

Anna Voskresenskaya, Nadezhda Pozdeyeva, Yevgeniy Batkov, Tatyana Vasilyeva, Andrey Marakhonov, Richard A West, Jeffrey L Caplan, Ales Cvekl, Yan Wang, Melinda K Duncan

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Impact ofJournal of clinical medicine · 2026
    Article
  2. Article
  3. Review
  4. Reduction of lens size in PAX6-related aniridia.Experimental eye research · 2024
    Article
  5. Review
  6. Indian journal of ophthalmology · 2022
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Anna VoskresenskayaCheboksary Branch of The S. Fyodorov Eye Microsurgery Federal State Institution, Cheboksary, Russian Federation. Electronic address: vsolaris@mail.ru.
Nadezhda PozdeyevaCheboksary Branch of The S. Fyodorov Eye Microsurgery Federal State Institution, Cheboksary, Russian Federation; Postgraduate Medical Institute, Cheboksary, Russian Federation.
Yevgeniy BatkovCheboksary Branch of The S. Fyodorov Eye Microsurgery Federal State Institution, Cheboksary, Russian Federation.
Tatyana VasilyevaFederal State Budgetary Institution «Research Center for Medical Genetics», Moscow, Russian Federation.
Andrey MarakhonovFederal State Budgetary Institution «Research Center for Medical Genetics», Moscow, Russian Federation.
Richard A WestThe University of Delaware Bioimaging and Flow Cytometry Core Facility, University of Delaware, Newark, DE, USA.
Jeffrey L CaplanThe University of Delaware Bioimaging and Flow Cytometry Core Facility, University of Delaware, Newark, DE, USA.
Ales CveklThe Departments Ophthalmology and Visual Sciences, and Genetics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Yan WangDepartment of Biological Sciences, University of Delaware, Newark, DE, USA.
Melinda K DuncanDepartment of Biological Sciences, University of Delaware, Newark, DE, USA. Electronic address: duncanm@udel.edu.
University of Delaware · USIntersectoral Research and Technology Complex Eye Microsurgery · RUResearch Centre for Medical Genetics · RUAlbert Einstein College of Medicine · US

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Anjana Narayan Bhat · 2012 to 2026
$67.2M
PAX-6 AS A KEY REGULATOR OF LENS DEVELOPMENTR01EY012200 · NEI · YESHIVA UNIVERSITY · PI CVEKL, ALES · 2000 to 2025
$13.1M
The mechanisms underlying posterior capsular opacificationR01EY028597 · NEI · UNIVERSITY OF DELAWARE · PI DUNCAN, MELINDA K · 2018 to 2021
$1.5M
Acquisition of a Zeiss LSM710 Confocal MicroscopeS10RR027273 · NCRR · UNIVERSITY OF DELAWARE · PI DUNCAN, MELINDA K · 2010 to 2010
$494k
NCRR NIH HHS S10 RR027273NEI NIH HHS R01 EY012200NEI NIH HHS R01 EY028597NIGMS NIH HHS P20 GM103446
6 · The paper itself

Abstract

Congenital aniridia is caused by heterozygous mutations in the PAX6 gene. In this disease, congenital iris and foveal hypoplasia is associated with juvenile onset cataract, glaucoma, and corneal keratopathy. In rodents, Pax6 mutations result in a congenital reduction in ocular size that is not typically described in human aniridia. Here, the ocular morphometry of aniridia patients is compared with the lens phenotype of Pax6

Indexed as

AdolescentAdultAgedAnimalsAniridiaAnterior ChamberAxial Length, EyeCataractChildChild, PreschoolDisease Models, AnimalFemaleHumansInfantLens, CrystallineMalePAX6 protein, humanPax6 protein, mousePAX6 Transcription FactorAniridiaHaploinsufficiencyLensMorphometryPAX6Sey

Identifiers

PMID33248069
PMCPMC7867623
OpenAlexW3110492775

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.