Evidence map›Paper›PMID 33248061›Full record

ArticleBrain research2021

Effects of fibrinogen synthesis inhibition on vascular cognitive impairment during traumatic brain injury in mice.

Nino Muradashvili, Mariam Charkviani, Nurul Sulimai, Neetu Tyagi, Jeff Crosby, David Lominadze

Open access · greenAbstract read
In one paragraph

Article in Brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. CSF fibrinogen predicts longitudinal Tau accumulation in cognitively unimpaired older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. The multifaceted roles of activating transcription factor 3 (ATF3) in inflammatory responses - Potential target to regulate neuroinflammation in acute brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Fibrinogen and/or Fibrin as a Cause of Neuroinflammation.Online journal of neurology and brain disorders · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Nino MuradashviliDepartment of Physiology, University of Louisville, School of Medicine, Louisville, KY, USA; Department of Basic Medicine, Caucasus International University, Tbilisi, Georgia.
Mariam CharkvianiDepartment of Physiology, University of Louisville, School of Medicine, Louisville, KY, USA.
Nurul SulimaiDepartment of Surgery, USF Health-Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Neetu TyagiDepartment of Physiology, University of Louisville, School of Medicine, Louisville, KY, USA.
Jeff CrosbyIonis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
David LominadzeDepartment of Physiology, University of Louisville, School of Medicine, Louisville, KY, USA; Department of Surgery, USF Health-Morsani College of Medicine, University of South Florida, Tampa, FL, USA; Kentucky Spinal Cord Research Center, University of Louisville, School of Medicine, Louisville, KY, USA. Electronic address: dlominadze@usf.edu.
University of Louisville · USCaucasus International University · GEIonis Pharmaceuticals (United States) · USUniversity of South Florida · US

Funding

Mechanisms of Homocysteine-Induced Fibrinogen-Amyloid Plaque FormationR01NS084823 · NINDS · UNIVERSITY OF LOUISVILLE · PI LOMINADZE, DAVID, TYAGI, SURESH C. · 2013 to 2017
$2.7M
Mechanisms of neurodegeneration by a fibrinogen-containing protein complex during traumatic brain injuryR01HL146832 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI LOMINADZE, DAVID · 2019 to 2022
$1.5M
NHLBI NIH HHS R01 HL146832NINDS NIH HHS R01 NS084823
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is associated with increased blood content of fibrinogen (Fg), called hyperfibrinogenemia (HFg), which results in enhanced cerebrovascular permeability and leads to short-term memory (STM) reduction. Previously, we showed that extravasated Fg was deposited in the vasculo-astrocyte interface and was co-localized with cellular prion protein (PrP

Indexed as

Activating Transcription Factor 3AnimalsAstrocytesBrainBrain Injuries, TraumaticCerebrovascular CirculationCognitive DysfunctionFibrinogenGene ExpressionGene Expression RegulationMaleMemory, Short-TermMiceMice, Inbred C57BLPermeabilityPrion ProteinsActivating Transcription Factor 3Atf3 protein, mouseFibrinogenPrion ProteinsRNA, AntisenseCortical contusion injuryFg-ASOFg-PrP(C) complexShort-term memory

Identifiers

PMID33248061
PMCPMC7757857
OpenAlexW3107484752

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.