Evidence map›Paper›PMID 33247928›Full record

ArticlePathogens and disease2021

Chlamydia pneumoniae and Mycoplasma pneumoniae in children with cystic fibrosis: impact on bacterial respiratory microbiota diversity.

Laure F Pittet, Claire Bertelli, Valentin Scherz, Isabelle Rochat, Chiara Mardegan, René Brouillet, Katia Jaton, Anne Mornand, Laurent Kaiser, Klara Posfay-Barbe and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. From coughs to complications: the story ofJournal of medical microbiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Laure F PittetUnit of Pediatric Infectious Disease and Vaccinology, Department Women-Mother-Child, University Hospital Centre and University of Lausanne, 46 Rue du Bugnon, 1011 Lausanne, Switzerland.
Claire BertelliInstitute of Microbiology, University Hospital Centre and University of Lausanne, 48 Rue du Bugnon, 1011 Lausanne, Switzerland.
Valentin ScherzInstitute of Microbiology, University Hospital Centre and University of Lausanne, 48 Rue du Bugnon, 1011 Lausanne, Switzerland.
Isabelle RochatPediatric Pulmonology Unit, Division of General Pediatrics, Department of Pediatrics, University Hospital Centre and University of Lausanne, 46 Rue du Bugnon, 1011 Lausanne, Switzerland.
Chiara MardeganUnit of Pediatric Infectious Disease, Division of General Pediatrics, Department of Pediatrics, University Hospitals of Geneva, 6 Rue Willy Donzé, 1211 Geneva, Switzerland.
René BrouilletInstitute of Microbiology, University Hospital Centre and University of Lausanne, 48 Rue du Bugnon, 1011 Lausanne, Switzerland.
Katia JatonInstitute of Microbiology, University Hospital Centre and University of Lausanne, 48 Rue du Bugnon, 1011 Lausanne, Switzerland.
Anne MornandUnit of Pediatric Respiratory Disease, Division of General Pediatrics, Department of Pediatrics, University Hospitals of Geneva, 6 Rue Willy Donzé, 1211 Geneva, Switzerland.
Laurent KaiserLaboratory of Virology, Division of Infectious Diseases, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, 4 Rue G. Perret-Gentil, 1211 Geneva, Switzerland.
Klara Posfay-BarbeUnit of Pediatric Infectious Disease, Division of General Pediatrics, Department of Pediatrics, University Hospitals of Geneva, 6 Rue Willy Donzé, 1211 Geneva, Switzerland.
Sandra A AsnerUnit of Pediatric Infectious Disease and Vaccinology, Department Women-Mother-Child, University Hospital Centre and University of Lausanne, 46 Rue du Bugnon, 1011 Lausanne, Switzerland.
Gilbert GreubInstitute of Microbiology, University Hospital Centre and University of Lausanne, 48 Rue du Bugnon, 1011 Lausanne, Switzerland.
University of Lausanne · CHUniversity Hospital of Geneva · CHUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe contribution of intracellular and fastidious bacteria in Cystic fibrosis (CF) pulmonary exacerbations, and progressive lung function decline remains unknown. This project aimed to explore their impact on bacterial microbiota diversity over time in CF children.

methodsSixty-one children enrolled in the MUCOVIB multicentre prospective cohort provided 746 samples, mostly nasopharyngeal swabs, throat swabs and sputa which were analysed using culture, specific real-time qPCRs and 16S rRNA amplicon metagenomics.

resultsChlamydia pneumoniae (n = 3) and Mycoplasma pneumoniae (n = 1) were prospectively documented in 6.6% of CF children. Microbiota alpha-diversity in children with a documented C. pneumoniae was highly variable, similarly to children infected with Staphylococcus aureus or Pseudomonas aeruginosa. The transition from routine follow-up visits to pulmonary exacerbation (n = 17) yielded variable changes in diversity indexes with some extreme loss of diversity.

conclusionsThe high rate of C. pneumoniae detection supports the need for regular screenings in CF patients. A minor impact of C. pneumoniae on the microbial community structure was documented. Although detected in a single patient, M. pneumoniae should also be considered as a possible aetiology of lung infection in CF subjects.

Indexed as

MicrobiotaBiodiversityChildChild, PreschoolChlamydophila InfectionsChlamydophila pneumoniaeCystic FibrosisDNA, BacterialHumansMetagenomicsMycoplasma pneumoniaePneumonia, MycoplasmaProspective StudiesRespiratory SystemRNA, Ribosomal, 16SSputumDNA, BacterialRNA, Ribosomal, 16SChlamydialescystic fibrosisintracellular bacteriametagenomicspneumoniapulmonary exacerbation

Identifiers

PMID33247928
PMCPMC7787906
OpenAlexW3107226038

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.