ArticleEuropean heart journal. Cardiovascular Imaging2021
Non-calcific aortic tissue quantified from computed tomography angiography improves diagnosis and prognostication of patients referred for transcatheter aortic valve implantation.
Article in European heart journal. Cardiovascular Imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06136689 (Role of Aortic Valve Composition in Pathophysiology and Diagnosis of Aortic Stenosis), which is not on this map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Aortic Valve Composition in Pathophysiology and Diagnosis of Aortic Stenosis
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Moderate aortic stenosis: diagnostic pitfalls and the role of multimodality imaging in risk stratification and clinical management.Cardiovascular ultrasound · 2026Review
- How to Individualize Coronary Assessment and Revascularization in Severe AS Patients Undergoing TAVI in the Era of Lifetime Management?Journal of clinical medicine · 2026Review
- Interplay between parathyroid hormone concentration and valvular and aortic calcifications.Archives of medical science : AMS · 2026Article
- Morphology and calcification characterization in patients undergoing TAVI: A 3D statistical shape modelling study.PLOS digital health · 2025Article
- Characterization of Aortic Valve Stenosis by CT Angiography in a Diverse US Cohort.Circulation. Cardiovascular imaging · 2025Article
- Thrombus characterisation and evolution of hypoattenuating leaflet thickening after transcatheter aortic valve implantation.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Article
- Prothrombotic States in Transcatheter Heart Valve Leaflet Thrombosis (PROSTHESIS): Rationale and Early Results of the Observational Cohort Study.Journal of cardiovascular development and disease · 2025Article
- Wild-type transthyretin cardiac amyloidosis and aortic stenosis: Can carpal tunnel syndrome help distinguish the chicken from the egg?Journal of internal medicine · 2025Article
- 2024 Update on Cerebral Embolic Protection After Transcatheter Aortic Valve Replacement.Journal of clinical medicine · 2024Review
- Quantification of Aortic Valve Fibrotic and Calcific Tissue from CTA: Prospective Comparison with Histology.Radiology · 2024Article
- Advanced Cardiac Imaging in the Assessment of Aortic Stenosis.Journal of cardiovascular development and disease · 2023Review
- Early Heart Rate Recovery after a 6-min Walking Test Predicts Clinical Benefits in Patients after Percutaneous Aortic Valve Implantation.International journal of environmental research and public health · 2023Article
- Latest Advances in Multimodality Imaging of Aortic Stenosis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Review
- Models and Techniques to Study Aortic Valve CalcificationFrontiers in pharmacology · 2022Review
- Sex-Specific Cell Types and Molecular Pathways Indicate Fibro-Calcific Aortic Valve Stenosis.Frontiers in immunology · 2022Article
- Diagnostic Work-Up of the Aortic Patient: An Integrated Approach toward the Best Therapeutic Option.Journal of clinical medicine · 2021Review
- Head-to-Head Comparison of Different Software Solutions for AVC Quantification Using Contrast-Enhanced MDCT.Journal of clinical medicine · 2021Article
- Neurocognitive Status after Aortic Valve Replacement: Differences between TAVI and Surgery.Journal of clinical medicine · 2021Review
- Preprocedural CT angiography and machine learning for mortality prediction after transcatheter aortic valve replacement.Progress in cardiovascular diseasesArticle
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Authors and funding
21 authors at 8 institutions in 2 countries.
Funding
Abstract
aimsWe aimed to investigate the role of aortic valve tissue composition from quantitative cardiac computed tomography angiography (CTA) in patients with severe aortic stenosis (AS) for the differentiation of disease subtypes and prognostication after transcatheter aortic valve implantation (TAVI). METHODS AND
resultsOur study included 447 consecutive AS patients from six high-volume centres reporting to a prospective nationwide registry of TAVI procedures (POL-TAVI), who underwent cardiac CTA before TAVI, and 224 matched controls with normal aortic valves. Components of aortic valve tissue were identified using semi-automated software as calcific and non-calcific. Volumes of each tissue component and composition [(tissue component volume/total tissue volume) × 100%] were quantified. Relationship of aortic valve composition with clinical outcomes post-TAVI was evaluated using Valve Academic Research Consortium (VARC)-2 definitions.High-gradient (HG) AS patients had significantly higher aortic tissue volume compared to low-flow low-gradient (LFLG)-AS (1672.7 vs. 1395.3 mm3, P < 0.001) as well as controls (509.9 mm3, P < 0.001), but increased non-calcific tissue was observed in LFLG compared to HG patients (1063.6 vs. 860.2 mm3, P < 0.001). Predictive value of aortic valve calcium score [area under the curve (AUC) 0.989, 95% confidence interval (CI): 0.981-0.996] for severe AS was improved after addition of non-calcific tissue volume (AUC 0.995, 95% CI: 0.991-0.999, P = 0.011). In the multivariable analysis of clinical and quantitative computed tomography parameters of aortic valve tissue, non-calcific tissue volume [odds ratio (OR) 5.2, 95% CI 1.8-15.4, P = 0.003] and history of stroke (OR 2.6, 95% CI 1.1-6.5, P = 0.037) were independent predictors of 30-day major adverse cardiovascular event (MACE).
conclusionQuantitative CTA assessment of aortic valve tissue volume and composition can improve detection of severe AS, differentiation between HG and LFLG-AS in patients referred for TAVI as well as prediction of 30-day MACEs post-TAVI, over the current clinical standard.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.