Evidence map›Paper›PMID 33247673›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2020

Clinical Implication of Toll-Like Receptors (TLR2 and TLR4) in Acute Myeloid Leukemia Patients.

Salah Aref, Al Shaimaa Mansoura Abd Elmaksoud, Sherin Abd Elaziz, Mohamed Mabed, Mohamed Ayed

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Article in Asian Pacific journal of cancer prevention : APJCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Salah ArefHematology Unit, Department of Clinical pathology, Mansoura Faculty of Medicine, Mansoura University, Egypt.ORCID 0000-0002-4822-5204
Al Shaimaa Mansoura Abd ElmaksoudHematology Unit, Department of Clinical pathology, Mansoura Faculty of Medicine, Mansoura University, Egypt.
Sherin Abd ElazizHematology Unit, Department of Clinical pathology, Mansoura Faculty of Medicine, Mansoura University, Egypt.
Mohamed MabedHematology Unit, Mansoura University Oncology Center, Mansoura University, Egypt.
Mohamed AyedHematology Unit, Department of Clinical pathology, Mansoura Faculty of Medicine, Mansoura University, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundsToll-like receptors 2; 4 (TLR2;4) are an essential component of the innate immunity and play an important role in immune-surveillance and immune response to various microorganisms. This study aimed to investigate the association between TLR2 and TLR4 polymorphism and the risk of acquiring severe infections, and impact on AML patient's outcome. SUBJECTS AND

methodsUsing polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP); we analyzed three SNPs in the TLR2 (Arg753Gln) and TLR4 (Asp299Gly and Thr399Ile) in 120 AML patients and 100 healthy control subjects.

resultsNo significant differences in genotype or alleles frequency between healthy controls and AML patients regarding TLR2 Arg753Gln, TLR4 Asp299Gly and TLR4 Thr399Ile polymorphisms (P>0.05 for all). Neutropenic fever was detected in 110 out of 120 (91.7%) of the studied AML patients. The sepsis and pneumonia were identified in 20 out of 120 patients (16.7%). The incidence of sepsis was associated with TLR2 Arg753Gln: AG genotypes, A allele and TLR4 Asp299Gly: CT genotype and C allele as compared to other genotypes and alleles. Moreover; TLR2 (Arg753Gln) GG polymorphisms significantly associated with shortest overall survival (OS) and shortest disease-free survival (DFS); while TLR4 polymorphisms affect the DSF only but not OS. In AML patients TLR2 Arg753Gln gene polymorphism is associated with high susceptibility to sepsis and TLR4 (Asp299Gly and Thr399Ile) gene polymorphism is associated with high susceptibility for both pneumonia; and sepsis.

conclusionTLR2 Arg753Gln (AG; GG genotype) polymorphisms are associated with shortest OS and DFS. Moreover; significant association between TLR2 polymorphisms, TLR4 Arg753Gln polymorphisms and risk of severe infections in AML patients was documented.<br />.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAdolescentAdultAgedBiomarkers, TumorCase-Control StudiesFemaleFollow-Up StudiesGenotypeHumansLeukemia, Myeloid, AcuteMaleMiddle AgedPrognosisToll-Like Receptor 2Biomarkers, TumorTLR2 protein, humanTLR4 protein, humanToll-Like Receptor 2Toll-Like Receptor 4AMLpolymorphismsTLR2TLR4

Identifiers

PMID33247673
PMCPMC8033142

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.