Evidence map›Paper›PMID 33247672›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2020

Effects of Quinacrine on Expression of Hippo signaling Pathway Components (LATS1, LATS2, and YAP) in Human Breast Cancer Stem Cells.

Soroush Darbankhales, Reza Mirfakhraie, Hossein Ghahremani, Mohsen Asadolahi, Kobra Saket-Kisomi, Lily Safakish, Sepideh Darbeheshti, Zahra Ganjkhanlou, Siamak Salami, Majid Sirati-Sabet

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PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Soroush DarbankhalesDepartment of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID 0000-0001-9656-9821
Reza MirfakhraieDepartment of Medical Genetic, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID 0000-0003-1709-8975
Hossein GhahremaniDepartment of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-7663-0901
Mohsen AsadolahiDepartment of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-2323-8500
Kobra Saket-KisomiDepartment of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-9802-9738
Lily SafakishDepartment of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-0020-0251
Sepideh DarbeheshtiDepartment of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID 0000-0001-6661-0854
Zahra GanjkhanlouDepartment of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID 0000-0001-6173-0240
Siamak SalamiDepartment of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID 0000-0003-0393-5058
Majid Sirati-SabetDepartment of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-8163-7075
Shahid Beheshti University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe Hippo signaling pathway has important role in the pathogenesis of some tumors. Breast cancer is the most prevalent cancer among females in the world. In recent years, various articles referred to inhibiting effect of quinacrine, a derivative of 9-aminoacridine, on the growth of several types of cancer cells. In this study, we evaluated the effect of quinacrine on expression of LATS1, LATS2, and YAP genes of the Hippo signaling pathway and YAP level in human breast cancer stem cells (MDA-MB 231 cell line). This cell line of breast cancer expresses the triple negative characteristics.

methodsMDA-MB 231 cells was treated with 0.5 µM of quinacrine for 3 days. The dose was selected using MTT assays. The expression of genes was quantified by Real-time PCR. The protein expression was performed by Western blotting. Significance of observations were checked by means of Mann-Whitney test using p.

Indexed as

Antineoplastic AgentsApoptosisBiomarkers, TumorBreast NeoplasmsCell Cycle ProteinsCell ProliferationFemaleGene Expression Regulation, NeoplasticHippo Signaling PathwayHumansNeoplastic Stem CellsProtein Serine-Threonine KinasesQuinacrineTranscription FactorsTumor Cells, CulturedTumor Suppressor ProteinsAntineoplastic AgentsBiomarkers, TumorCell Cycle ProteinsLATS1 protein, humanLATS2 protein, humanProtein Serine-Threonine KinasesQuinacrineTranscription FactorsTumor Suppressor ProteinsYY1AP1 protein, humanCancer stem cellsHippo signaling pathwayMDA-MB 231quinacrinetriple negative breast cancer

Identifiers

PMID33247672
PMCPMC8033116
OpenAlexW3107632371

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.