Evidence map›Paper›PMID 33247632›Full record

ArticleBrain and behavior2021

Impact of COVID-19 pandemic lockdown on narcolepsy type 1 management.

Emanuela Postiglione, Fabio Pizza, Francesca Ingravallo, Luca Vignatelli, Marco Filardi, Anastasia Mangiaruga, Elena Antelmi, Monica Moresco, Claudia Oriolo, Uberto Pagotto and 1 more

Open access · goldAbstract read
In one paragraph

Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Adjustment to lockdown in children and adolescents with narcolepsy in France.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Article
  4. Article
  5. Article
  6. Sleeping through a pandemic: impact of COVID-19-related restrictions on narcolepsy and idiopathic hypersomnia.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. A practical guide to the pharmacological and behavioral therapy of Narcolepsy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Emanuela PostiglioneDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.ORCID 0000-0003-2058-2047
Fabio PizzaDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.ORCID 0000-0003-2294-9551
Francesca IngravalloDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.ORCID 0000-0002-5194-375X
Luca VignatelliIRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.ORCID 0000-0002-9051-7091
Marco FilardiDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.ORCID 0000-0001-9702-8314
Anastasia MangiarugaDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.ORCID 0000-0002-9057-2883
Elena AntelmiNeurology Unit, Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.ORCID 0000-0003-1739-6139
Monica MorescoIRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.ORCID 0000-0003-4316-5684
Claudia OrioloEndocrinology and Diabetes Prevention and Care Unit, Department of Medical and Surgical Sciences (DIMEC), S. Orsola Policlinic, University of Bologna, Bologna, Italy.
Uberto PagottoEndocrinology and Diabetes Prevention and Care Unit, Department of Medical and Surgical Sciences (DIMEC), S. Orsola Policlinic, University of Bologna, Bologna, Italy.ORCID 0000-0003-4182-3110
Giuseppe PlazziIRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.ORCID 0000-0002-1051-0472
University of Bologna · ITIstituto delle Scienze Neurologiche di Bologna · ITUniversity of Modena and Reggio Emilia · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesNarcolepsy type 1 (NT1) is a chronic rare hypersomnia of central origin requiring a combination of behavioral and pharmacological treatments. During the coronavirus disease 2019 (COVID-19) pandemic, in Italy the population was forced into a lockdown. With this study, we aimed to describe the lockdown impact on NT1 symptom management, according to different patients' working schedule.

methodsIn the period between 10 April and 15 May 2020, we performed routine follow-up visits by telephone (as recommended during the COVID-19 emergency) to 50 patients >18 years old (40% males) under stable long-term treatment. We divided patients into three groups: unchanged working schedule, forced working/studying at home, and those who lost their job ("lost occupation"). Current sleep-wake habit and symptom severity were compared with prelockdown assessment (six months before) in the three patient groups.

resultsAt assessment, 20, 22, and eight patients belonged to the unchanged, working/studying at home, and lost occupation groups, respectively. While in the lost occupation group, there were no significant differences compared with prepandemic assessment, the patients with unchanged schedules reported more nocturnal awakenings, and NT1 patients working/studying at home showed an extension of nocturnal sleep time, more frequent daytime napping, improvement of daytime sleepiness, and a significant increase in their body mass index. Sleep-related paralysis/hallucinations, automatic behaviors, cataplexy, and disturbed nocturnal sleep did not differ.

conclusionsNarcolepsy type 1 patients working/studying at home intensified behavioral interventions (increased nocturnal sleep time and daytime napping) and ameliorated daytime sleepiness despite presenting with a slight, but significant, increase of weight.

Indexed as

QuarantineAdultCOVID-19EmploymentFemaleHumansItalyMaleMiddle AgedNarcolepsyPandemicsSARS-CoV-2Severity of Illness IndexTelemedicinebehavioral therapyCOVID-19lockdownnarcolepsy type 1smart working

Identifiers

PMID33247632
PMCPMC7744913
OpenAlexW3110234024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.