Evidence map›Paper›PMID 33247543›Full record

ReviewJournal of cellular and molecular medicine2021

Advances on liver cell-derived exosomes in liver diseases.

Yan Jiao, Ping Xu, Honglin Shi, Dexi Chen, Hongbo Shi

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cellular and molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 69 citations in OpenAlex.

  1. Review
  2. Article
  3. 80 years of extracellular vesicles: from discovery to clinical translation.Extracellular vesicles and circulating nucleic acids · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Role of Extracellular Vesicles in Liver Diseases.Life (Basel, Switzerland) · 2023
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yan JiaoBeijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-7486-5782
Ping XuBeijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Honglin ShiBeijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Dexi ChenBeijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Hongbo ShiBeijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CN

Funding

Beijing Municipal Medical Research Institute Public Welfare Development and Reform Pilot Project jingyiyan2019-6The Chinese Foundation for Hepatitis Prevention and Control TQGB20190050The National Natural Science Foundation of China 81672026
6 · The paper itself

Abstract

Exosomes are extracellular vesicles with diameters ranging from 30 to 150 nm, which contain several donor cell-associated proteins as well as mRNA, miRNA, and lipids and coordinate multiple physiological and pathological functions through horizontal communication between cells. Almost all types of liver cells, such as hepatocytes and Kupffer cells, are exosome-releasing and/or exosome-targeted cells. Exosomes secreted by liver cells play an important role in regulating general physiological functions and also participate in the onset and development of liver diseases, including liver cancer, liver injury, liver fibrosis and viral hepatitis. Liver cell-derived exosomes carry liver cell-specific proteins and miRNAs, which can be used as diagnostic biomarkers and treatment targets of liver disease. This review discusses the functions of exosomes derived from different liver cells and provides novel insights based on the latest developments regarding the roles of exosomes in the diagnosis and treatment of liver diseases.

Indexed as

AnimalsBiomarkersExosomesHepatocytesHumansLiver DiseasesModels, BiologicalBiomarkersbiomarkerexosomehepatocyteliver disease

Identifiers

PMID33247543
PMCPMC7810930
OpenAlexW3110561457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.