Evidence map›Paper›PMID 33247433›Full record

ArticleJournal of clinical pharmacy and therapeutics2021

Characterization of Isavuconazole serum concentrations after enteral feeding tube administration in a hospitalized cohort: A case series.

Justin Spivey, Rebekah Wrenn, Beiyu Liu, Eileen Maziarz, Bridgette Kram

Open access · greenAbstract readCase Reports
In one paragraph

Article in Journal of clinical pharmacy and therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Justin SpiveyDepartment of Pharmacy, Duke University Hospital, Durham, NC, USA.ORCID https://orcid.org/0000-0002-4349-8932
Rebekah WrennDepartment of Pharmacy, Duke University Hospital, Durham, NC, USA.
Beiyu LiuDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA.
Eileen MaziarzDepartment of Medicine (Infectious Diseases Division), Duke University Hospital, Durham, NC, USA.
Bridgette KramDepartment of Pharmacy, Duke University Hospital, Durham, NC, USA.
Duke University Hospital · USDuke University · US

Funding

Support for QA/QC for Prior Approval ProcessUL1TR002553 · NCATS · DUKE UNIVERSITY · PI LI, JENNIFER S, MCNAMARA, JAMES O. · 2018 to 2023
$58.5M
NCATS NIH HHS UL1 TR002553NCATS NIH HHS UL1TR002553
6 · The paper itself

Abstract

WHAT IS KNOWN AND

objectiveInvasive fungal infections often occur in patients with comorbidities that complicate oral administration. Serum concentrations of isavuconazole were characterized after enteral tube administration. CASE DESCRIPTION: Thirteen of 14 isavuconazole concentrations were >1 mg/dl (median 1.6 mg/dl) among those receiving enteral tube administration, which was comparable to intravenous (median 1.9 mg/dl). Higher concentrations were observed during oral administration (median 3 mg/dl). WHAT IS NEW AND

conclusionAdministration of isavuconazole via tube resulted in concentrations comparable to FDA-approved routes of administration. This route may be feasible and appropriate for select patients.

Indexed as

AdultAntifungal AgentsDrug Administration RoutesEnteral NutritionFemaleHumansInvasive Fungal InfectionsMaleMiddle AgedNitrilesPyridinesTriazolesAntifungal AgentsisavuconazoleNitrilesPyridinesTriazolesenteral administrationinvasive fungal infectionisavuconazoletherapeutic drug monitoring

Identifiers

PMID33247433
PMCPMC7969444
OpenAlexW3107602555

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.