Evidence map›Paper›PMID 33247421›Full record

ArticleDigestive diseases and sciences2021

HIPK3 Circular RNA Promotes Metastases of HCC Through Sponging miR-338-3p to Induce ZEB2 Expression.

Weizhi Li, Hui Xue, Yingchao Li, Peijie Li, Fuquan Ma, Mengying Liu, Shuzhen Kong

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  5. [Research Progress of Circular RNA CircHIPK3 in Non-small Cell Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024
    Review
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  8. Article
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  10. Article
  11. Article
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  14. Effects of Circ_0109046 Regulating Mir-338-3p on the Malignant Behavior of A2780 Cells.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
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  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Weizhi LiDepartment of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Hui XueDepartment of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Yingchao LiDepartment of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Peijie LiDepartment of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Fuquan MaDepartment of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Mengying LiuDepartment of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Shuzhen KongDepartment of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xi'an, 710004, China. kongshuzhensz@163.com.ORCID 0000-0002-6156-4884
First Affiliated Hospital of Xi'an Jiaotong University · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUpregulation of circHIPK3 has been observed in several kinds of malignancies. However, the mechanisms of circHIPK3 in HCC metastases remains unclear. We investigated the role and the mechanisms of circHIPK3 in the development of HCC.

methodsHCC tissues and paired adjacent non-tumor tissues of surgical patients were used to evaluate circHIPK3 expression. A series of biological experiments had been taken to evaluate the pro-metastatic ability of circHIPK3 during HCC development in vitro and in vivo. The potential mechanisms of circHIPK3 in HCC development were identified by RT-qPCR, Western blot, RIP, and luciferase reporter assays.

resultsCircHIPK3 expression is significantly upregulated during HCC development. Overexpression of circHIPK3 promotes cell migration, invasion, and metastases in vitro and in vivo. CircHIPK3 promoted HCC metastases by sponging miR-338-3p to regulate EMT-associated proteins E-cadherin, vimentin, and ZEB2 expression.

conclusionCircHIPK3 plays a regulatory role in metastatic HCC by sponging miR-338-3p to induce ZEB2 expression, thus promoting EMT procession.

Indexed as

AnimalsCarcinoma, HepatocellularCell Line, TumorGene Expression Regulation, NeoplasticHumansIntracellular Signaling Peptides and ProteinsLiver NeoplasmsLung NeoplasmsMiceMice, NudeMicroRNAsNeoplasms, ExperimentalProtein Serine-Threonine KinasesRNA, CircularUp-RegulationZinc Finger E-box Binding Homeobox 2HIPK3 protein, humanIntracellular Signaling Peptides and ProteinsMicroRNAsMIRN338 microRNA, humanProtein Serine-Threonine KinasesRNA, CircularZEB2 protein, humanZinc Finger E-box Binding Homeobox 2CircHIPK3EMTHCCmiR-338-3pZEB2

Identifiers

PMID33247421
OpenAlexW3109388216

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.