Evidence map›Paper›PMID 33247354›Full record

ArticleCancer causes & control : CCC2021

Early-life cancer, infertility, and risk of adverse pregnancy outcomes: a registry linkage study in Massachusetts.

Leslie V Farland, Judy E Stern, Sunah S Hwang, Chia-Ling Liu, Howard Cabral, Richard Knowlton, Susan T Gershman, Charles C Coddington, Stacey A Missmer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Leslie V FarlandDepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave, PO Box: 245211, Tucson, AZ, 85724, USA. lfarland@email.arizona.edu.ORCID http://orcid.org/0000-0001-7455-8531
Judy E SternDepartment of Obstetrics and Gynecology, Dartmouth-Hitchcock, Lebanon, NH, USA.
Sunah S HwangDepartment of Pediatrics, Section of Neonatology, University of Colorado School of Medicine, Aurora, CO, USA.
Chia-Ling LiuMassachusetts Department of Public Health, Bureau of Family Health and Nutrition, Boston, MA, USA.
Howard CabralDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Richard KnowltonMassachusetts Cancer Registry, Office of Data Management and Outcomes Assessment, Office of Population Health, Massachusetts Department of Public Health, Boston, MA, USA.
Susan T GershmanMassachusetts Cancer Registry, Office of Data Management and Outcomes Assessment, Office of Population Health, Massachusetts Department of Public Health, Boston, MA, USA.
Charles C CoddingtonDepartment of Obstetrics and Gynecology, Carolinas Medical Center/Atrium Health, Charlotte, NC, USA.
Stacey A MissmerDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Massachusetts Department of Public Health · USBoston University · USCarolinas Medical Center · USDartmouth–Hitchcock Medical Center · USGrand Rapids Community College · USUniversity of Arizona · USUniversity of Colorado Denver · US

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
Women's Health After Assisted Reproductive Technology: A Population-Based StudyR01HD067270 · NICHD · DARTMOUTH-HITCHCOCK CLINIC · PI DIOP, HAFSATOU, STERN, JUDY E · 2011 to 2020
$7.4M
Eunice Kennedy Shriver National Institute of Child Health and Human Development NIH R01HD067270NICHD NIH HHS R01 HD067270NIEHS NIH HHS P30 ES006694
6 · The paper itself

Abstract

purposeInvestigate the relationship between history of cancer and adverse pregnancy outcomes according to subfertility/fertility treatment.

methodsDeliveries (2004-2013) from Massachusetts (MA) Registry of Vital Records and Statistics were linked to MA assisted reproductive technology data, hospital discharge records, and Cancer Registry. The relative risks (RR) and 95% confidence intervals of adverse outcomes (gestational diabetes (GDM), gestational hypertension (GHTN), cesarean section (CS), low birth weight (LBW), small for gestational age (SGA), preterm birth (PTB), neonatal mortality, and prolonged neonatal hospital stay) were modeled with log-link and Poisson distribution generalized estimating equations. Differences by history of subfertility/fertility treatment were investigated with likelihood ratio tests.

resultsAmong 662,630 deliveries, 2,983 had a history of cancer. Women with cancer history were not at greater risk of GDM, GHTN, or CS. However, infants born to women with prior cancer had higher risk of LBW (RR: 1.19 [1.07-1.32]), prolonged neonatal hospital stay (RR: 1.16 [1.01-1.34]), and PTB (RR: 1.19 [1.07-1.32]). We found clinically and statistically significant differences in the relationship between cancer history and SGA by subfertility/fertility treatment (p value, test for heterogeneity = 0.02); among deliveries with subfertility or fertility treatment, those with a history of cancer experienced a greater risk of SGA (RRsubfertile: 1.36 [1.02-1.83]).

conclusionsWomen with a history of cancer had greater risk of some adverse pregnancy outcomes; this relationship varied by subfertility and fertility treatment.

Indexed as

AdolescentAdultCesarean SectionDiabetes, GestationalFemaleHumansHypertension, Pregnancy-InducedInfant, Low Birth WeightInfant, NewbornInfertilityMassachusettsNeoplasmsPregnancyPregnancy OutcomePremature BirthRegistriesCancer survivorsInfertilityLow birthweightNeonatal mortalityPregnancyPreterm birthSmall for gestational age

Identifiers

PMID33247354
PMCPMC7855547
OpenAlexW3110448294

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.