Evidence map›Paper›PMID 33247346›Full record

ArticleEuropean radiology2021

Comparison of automated and manual DWI-ASPECTS in acute ischemic stroke: total and region-specific assessment.

XiaoQing Cheng, XiaoQin Su, JiaQian Shi, QuanHui Liu, ChangSheng Zhou, Zheng Dong, Wei Xing, HaiTao Lu, ChengWei Pan, XiuLi Li and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Controversies in Treatment Methodologies in Cerebrovascular Surgery.Advances and technical standards in neurosurgery · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

XiaoQing ChengDepartment of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, 305 Zhongshan East Road, Nanjing, 210002, Jiangsu, China.
XiaoQin SuDepartment of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, 305 Zhongshan East Road, Nanjing, 210002, Jiangsu, China.
JiaQian ShiDepartment of Medical Imaging, Xuzhou Medical University, Xuzhou, Jiangsu, China.
QuanHui LiuDepartment of Medical Imaging, Xuzhou Medical University, Xuzhou, Jiangsu, China.
ChangSheng ZhouDepartment of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, 305 Zhongshan East Road, Nanjing, 210002, Jiangsu, China.
Zheng DongDepartment of Medical Imaging, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Wei XingRadiology Department, The Third Affiliated Hospital of Soochow University, Changzhou, China.
HaiTao LuRadiology Department, The Third Affiliated Hospital of Soochow University, Changzhou, China.
ChengWei PanDeepWise AI Lab, Beijing, China.
XiuLi LiDeepWise AI Lab, Beijing, China.
YiZhou YuDeepWise AI Lab, Beijing, China.
LongJiang ZhangDepartment of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, 305 Zhongshan East Road, Nanjing, 210002, Jiangsu, China. kevinzhlj@163.com.
GuangMing LuDepartment of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, 305 Zhongshan East Road, Nanjing, 210002, Jiangsu, China. cjr.luguangming@vip.163.com.ORCID http://orcid.org/0000-0003-4913-2314
Nanjing General Hospital of Nanjing Military Command · CNXuzhou Medical College · CNSoochow University · CN

Funding

the Key project of the National Natural Science Foundation of China 81830057the Major project of the National Natural Scientific Foundation of China 81790653
6 · The paper itself

Abstract

objectiveTo compare the DWI-Alberta Stroke Program Early Computed Tomography Score calculated by a deep learning-based automatic software tool (eDWI-ASPECTS) with the neuroradiologists' evaluation for the acute stroke, with emphasis on its performance on 10 individual ASPECTS regions, and to determine the reasons for inconsistencies between eDWI-ASPECTS and neuroradiologists' evaluation.

methodsThis retrospective study included patients with middle cerebral artery stroke who underwent MRI from 2010 to 2019. All scans were evaluated by eDWI-ASPECTS and two independent neuroradiologists (with 15 and 5 years of experience in stroke study). Inter-rater agreement and agreement between manual vs. automated methods for total and each region were evaluated by calculating Kendall's tau-b, intraclass correlation coefficient (ICC), and kappa coefficient.

resultsIn total, 309 patients met our study criteria. For total ASPECTS, eDWI-ASPECTS and manual raters had a strong positive correlation (Kendall's tau-b = 0.827 for junior raters vs. eDWI-ASPECTS; Kendall's tau-b = 0.870 for inter-raters; Kendall's tau-b = 0.848 for senior raters vs. eDWI-ASPECTS) and excellent agreement (ICC = 0.923 for junior raters and automated scores; ICC = 0.954 for inter-raters; ICC = 0.939 for senior raters and automated scores). Agreement was different for individual ASPECTS regions. All regions except for M5 region (κ = 0.216 for junior raters and automated scores), internal capsule (κ = 0.525 for junior raters and automated scores), and caudate (κ = 0.586 for senior raters and automated scores) showed good to excellent concordance.

conclusionThe eDWI-ASPECTS performed equally well as senior neuroradiologists' evaluation, although interference by uncertain scoring rules and midline shift resulted in poor to moderate consistency in the M5, internal capsule, and caudate nucleus regions. KEY POINTS: • The eDWI-ASPECTS based on deep learning perform equally well as senior neuroradiologists' evaluations. • Among the individual ASPECTS regions, the M5, internal capsule, and caudate regions mainly affected the overall consistency. • Uncertain scoring rules and midline shift are the main reasons for regional inconsistency.

Indexed as

Brain IschemiaIschemic StrokeStrokeAlbertaHumansObserver VariationReproducibility of ResultsRetrospective StudiesBrain ischemiaMagnetic resonance imagingMiddle cerebral arteryStroke

Identifiers

PMID33247346
OpenAlexW3106582149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.