ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021
Clinical value of C-reactive protein/albumin ratio in Guillain-Barré syndrome.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 16 citations in OpenAlex.
- C-Reactive Protein and Neurological Autoimmune Diseases: Bridging the Diagnostic and Pathogenic Gap.International journal of molecular sciences · 2026Review
- The Role of Serum Albumin as a Prognostic Marker in Guillain-Barré Syndrome: A Systematic Review.Journal of inflammation research · 2026Review
- C-reactive protein-to-albumin ratio predicts intensive care admission and disease severity in autoimmune encephalitis.Frontiers in immunology · 2026Article
- Predictive value of the preoperative C-reactive protein-to-albumin ratio for surgical site infection after percutaneous kyphoplasty: a single-center retrospective study.Frontiers in cellular and infection microbiology · 2025Article
- High Systemic Inflammatory Protein Index Is Associated with Clinically Ineffective Reperfusion in Acute Anterior Circulation Ischemic Stroke Patients Undergoing Endovascular Treatment.Molecular neurobiology · 2024Article
- The association between C-reactive protein to albumin ratio and 6-month neurological outcome in patients with in-hospital cardiac arrest.World journal of emergency medicine · 2024Article
- Review of the Predictive Value of Biomarkers in Sepsis Mortality.Emergency medicine international · 2024Review
- An S-like curve relationship between systemic inflammation response index (SIRI) and respiratory failure in GBS patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Association between C-reactive protein-to-albumin ratio and 6-month mortality in out-of-hospital cardiac arrest.Acute and critical care · 2022Article
- Increased systemic immune-inflammation index can predict respiratory failure in patients with Guillain-Barré syndrome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Influence of Hyperglycaemia and CRP on the Need for Mechanical Ventilation in Guillain-Barré Syndrome.Frontiers in neurology · 2022Article
- Lack of association between TREM2 rs75932628 variant and amyotrophic lateral sclerosis.Molecular biology reports · 2021Article
- Role of C-reactive protein in disease progression, diagnosis and management.Discoveries (Craiova, Romania)Review
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRespiratory failure in patients with Guillain-Barré syndrome (GBS) can lead to serious complications and dysfunctions, emphasizing the importance of early detection. The C-reactive protein-to-albumin ratio (CAR) is emerging as a novel inflammatory marker for predicting neurological outcome. We aimed to identify the association of CAR with respiratory failure and short-term outcome in GBS patients.
methodsA total of 200 patients diagnosed with GBS were retrospectively analyzed. Data were collected from an electronic database. The associations of C-reactive protein (CRP), albumin, and CAR at admission with outcomes were evaluated by logistic regression analysis. Using receiver operating characteristic curves, we calculated the cutoff value for the CAR and compared its discriminatory power with that of C-reactive protein alone.
resultsFifty-two (26%) patients showed poor short-term outcome, and 50 (25%) developed respiratory failure. CAR > 0.21 was an independent predictor of respiratory failure, and CAR > 0.19 was an independent predictor of poor short-term outcome. CAR showed a better predictive value than CRP alone. In addition, the c-index of the predictive nomogram for respiratory failure was higher when it included CAR (0.962) than when it did not (0.958). A similar result was observed for the predictive nomogram for poor short-term outcome (0.953 vs 0.947).
conclusionCAR > 0.21, a novel inflammatory biomarker, is independently associated with the occurrence of respiratory failure in GBS patients, while CAR > 0.19 is independently associated with poor short-term outcome. CAR may help identify GBS patients at high risk of poor prognosis.
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