Evidence map›Paper›PMID 33247200›Full record

ArticleScientific reports2020

Electrochemical degradation and saponification of porcine adipose tissue.

Tiffany T Pham, Anna M Stokolosa, Pamela A Borden, Kyle D Hansen, Ellen M Hong, Tatiana B Krasieva, Ryan H Sivoraphonh, Wesley J Moy, Andrew E Heidari, Lauren H Lee and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Tiffany T PhamBeckman Laser Institute and Medical Clinic, University of California - Irvine, Irvine, CA, 92612, USA.
Anna M StokolosaDepartment of Chemistry, Occidental College, Los Angeles, CA, 90041, USA.
Pamela A BordenBeckman Laser Institute and Medical Clinic, University of California - Irvine, Irvine, CA, 92612, USA.
Kyle D HansenBeckman Laser Institute and Medical Clinic, University of California - Irvine, Irvine, CA, 92612, USA.
Ellen M HongBeckman Laser Institute and Medical Clinic, University of California - Irvine, Irvine, CA, 92612, USA.
Tatiana B KrasievaBeckman Laser Institute and Medical Clinic, University of California - Irvine, Irvine, CA, 92612, USA.
Ryan H SivoraphonhBeckman Laser Institute and Medical Clinic, University of California - Irvine, Irvine, CA, 92612, USA.
Wesley J MoyBeckman Laser Institute and Medical Clinic, University of California - Irvine, Irvine, CA, 92612, USA.ORCID 0000-0002-6271-803X
Andrew E HeidariBeckman Laser Institute and Medical Clinic, University of California - Irvine, Irvine, CA, 92612, USA.
Lauren H LeeBeckman Laser Institute and Medical Clinic, University of California - Irvine, Irvine, CA, 92612, USA.
Eun-Hee KimBeckman Laser Institute-Korea, Dankook University College of Medicine, Cheonan-si, Chungnam, 31116, Republic of Korea.
Chung- Ho SunBeckman Laser Institute and Medical Clinic, University of California - Irvine, Irvine, CA, 92612, USA.
Wangcun JiaBeckman Laser Institute and Medical Clinic, University of California - Irvine, Irvine, CA, 92612, USA.
Ji -Hun MoDepartment of Otorhinolaryngology, Dankook University College of Medicine, Cheonan-siChungnam, 31116, Republic of Korea.
Sehwan KimDepartment of Biomedical Engineering, Dankook University College of Medicine, Cheonan-siChungnam, 31116, Republic of Korea.ORCID 0000-0002-5491-3732
Michael G HillDepartment of Chemistry, Occidental College, Los Angeles, CA, 90041, USA.
Brian J F WongBeckman Laser Institute and Medical Clinic, University of California - Irvine, Irvine, CA, 92612, USA. bjwong@uci.edu.
University of California, Irvine · USDankook University · KROccidental College · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI DURKIN, ANTHONY · 2012 to 2017
$7.0M
NCI NIH HHS 2P30CA062203-19NCI NIH HHS P30 CA062203NIBIB NIH HHS P41 EB015890NIBIB NIH HHS P41-EB015890
6 · The paper itself

Abstract

Body contouring achieved via subcutaneous adipose tissue reduction has notably advanced over the past century, from suction assisted lipectomy to techniques with reduced degrees of invasiveness including laser, radiofrequency, high frequency focused ultrasound, cryolipolysis, and drug-based injection approaches. These costly techniques have focused on damaging adipocyte cell membranes, hydrolyzing triglycerides (TGs), or inducing apoptosis. Here, we present a simple, low-cost technique, termed electrochemical lipolysis (ECLL). During ECLL, saline is injected into the subcutaneous adipose tissue, followed by insertion of needle electrodes and application of an electrical potential. Electrolysis of saline creates localized pH gradients that drive adipocyte death and saponification of TGs. Using pH mapping, various optical imaging techniques, and biochemical assays, we demonstrate the ability of ECLL to induce acid and base injury, cell death, and the saponification of triglycerides in ex vivo porcine adipose tissue. We define ECLL's potential role as a minimally-invasive, ultra-low-cost technology for reducing and contouring adipose tissue, and present ECLL as a potential new application of an emerging electrochemical redox based treatment modality.

Indexed as

LipolysisAdipose TissueAnimalsApoptosisBody ContouringElectrochemical TechniquesHydrogen-Ion ConcentrationSwineTriglyceridesTriglycerides

Identifiers

PMID33247200
PMCPMC7695738
OpenAlexW3108663865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.