ArticleNature communications2020
A FN-MdV pathway and its role in cerebellar multimodular control of sensorimotor behavior.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- A Systematic Review of Direct Outputs from the Cerebellum to the Brainstem and Diencephalon in Mammals.Cerebellum (London, England) · 2024Pooled it
- Neural circuits encode prior knowledge of temporal statistics.Nature neuroscience · 2026Article
- Cerebellar circuit computations for predictive motor control.Nature reviews. Neuroscience · 2025Review
- Cerebellar output neurons can impair non-motor behaviors by altering development of extracerebellar connectivity.Nature communications · 2025Article
- Neuronal dynamics of cerebellum and medial prefrontal cortex in adaptive motor timing.Nature communications · 2025Article
- The cerebellum engages multiple pre-motor pathways through a divergent-convergent architecture to shape whisker dynamics.Frontiers in neural circuits · 2025Article
- Cerebellar output neurons impair non-motor behaviors by altering development of extracerebellar connectivity.bioRxiv : the preprint server for biology · 2024Article
- Cerebellum Lecture: the Cerebellar Nuclei-Core of the Cerebellum.Cerebellum (London, England) · 2024Review
- Impact of enriched environment on motor performance and learning in mice.Scientific reports · 2024Article
- Excitatory nucleo-olivary pathway shapes cerebellar outputs for motor control.Nature neuroscience · 2023Article
- Cerebellar contribution to the regulation of defensive states.Frontiers in systems neuroscience · 2023Review
- Deconstruction of Vermal Cerebellum in Ramp Locomotion in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- BOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination.Signal transduction and targeted therapy · 2022Article
- Ventromedial Thalamus-Projecting DCN Neurons Modulate Associative Sensorimotor Responses in Mice.Neuroscience bulletin · 2022Article
- A Flexible Platform for Monitoring Cerebellum-Dependent Sensory Associative Learning.Journal of visualized experiments : JoVE · 2022Article
- Purkinje Cell Activity in the Medial and Lateral Cerebellum During Suppression of Voluntary Eye Movements in Rhesus Macaques.Frontiers in cellular neuroscience · 2022Article
- Cerebellar Circuits for Classical Fear Conditioning.Frontiers in cellular neuroscience · 2022Review
- Action-based organization of a cerebellar module specialized for predictive control of multiple body parts.Neuron · 2021Article
- Recent Advances in the Understanding of Specific Efferent Pathways Emerging From the Cerebellum.Frontiers in neuroanatomy · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cerebellum is crucial for various associative sensorimotor behaviors. Delay eyeblink conditioning (DEC) depends on the simplex lobule-interposed nucleus (IN) pathway, yet it is unclear how other cerebellar modules cooperate during this task. Here, we demonstrate the contribution of the vermis-fastigial nucleus (FN) pathway in controlling DEC. We found that task-related modulations in vermal Purkinje cells and FN neurons predict conditioned responses (CRs). Coactivation of the FN and the IN allows for the generation of proper motor commands for CRs, but only FN output fine-tunes unconditioned responses. The vermis-FN pathway launches its signal via the contralateral ventral medullary reticular nucleus, which converges with the command from the simplex-IN pathway onto facial motor neurons. We propose that the IN pathway specifically drives CRs, whereas the FN pathway modulates the amplitudes of eyelid closure during DEC. Thus, associative sensorimotor task optimization requires synergistic modulation of different olivocerebellar modules each provide unique contributions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.