Evidence map›Paper›PMID 33247159›Full record

ArticleScientific reports2020

Pharmacological characterisation of novel adenosine A

Kerry Barkan, Panagiotis Lagarias, Margarita Stampelou, Dimitrios Stamatis, Sam Hoare, Dewi Safitri, Karl-Norbert Klotz, Eleni Vrontaki, Antonios Kolocouris, Graham Ladds

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Cryo-EM structures of adenosine receptor ANature communications · 2024
    Article
  5. Article
  6. Assay-Dependent Inverse Agonism at the AACS pharmacology & translational science · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Discovery of a High Affinity Adenosine AACS medicinal chemistry letters · 2022
    Article
  11. Selective AACS medicinal chemistry letters · 2022
    Article
  12. Review
  13. Article
  14. Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor.ACS pharmacology & translational science · 2021
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Kerry BarkanDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK.
Panagiotis LagariasSection of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771, Athens, Greece.
Margarita StampelouSection of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771, Athens, Greece.
Dimitrios StamatisSection of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771, Athens, Greece.
Sam HoarePharmechanics LLC, 14 Sunnyside Drive South, Owego, NY, 13827, USA.
Dewi SafitriDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK.
Karl-Norbert KlotzInstitute of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9, 97078, Würzburg, Germany.
Eleni VrontakiSection of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771, Athens, Greece.
Antonios KolocourisSection of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771, Athens, Greece. ankol@pharm.uoa.gr.
Graham LaddsDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK. grl30@cam.ac.uk.
National and Kapodistrian University of Athens · GRUniversity of Cambridge · GBBandung Institute of Technology · IDUniversity of Würzburg · DE

Funding

Biotechnology and Biological Sciences Research Council BB/M00015X/2
6 · The paper itself

Abstract

The adenosine A

Indexed as

Adenosine A3 Receptor AntagonistsAnimalsBinding, CompetitiveBinding SitesCHO CellsCricetulusCyclic AMPDrug Evaluation, PreclinicalHumansKineticsMolecular Dynamics SimulationMutagenesis, Site-DirectedRadioligand AssayRatsReceptor, Adenosine A3Receptors, Purinergic P1Adenosine A3 Receptor AntagonistsADORA3 protein, humanCyclic AMPReceptor, Adenosine A3Receptors, Purinergic P1Recombinant Proteins

Identifiers

PMID33247159
PMCPMC7695835
OpenAlexW3107755701

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.