Evidence map›Paper›PMID 33247138›Full record

ArticleNature communications2020

Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates.

M D Fahlberg, R V Blair, L A Doyle-Meyers, C C Midkiff, G Zenere, K E Russell-Lodrigue, C J Monjure, E H Haupt, T P Penney, G Lehmicke and 9 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 2 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.

  1. Pooled it
  2. A Meta-Analysis of Rhesus Macaques (Comparative medicine · 2021
    Pooled it
  3. Article
  4. Review
  5. Coordinated expansion of CD163bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Observational
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. SARS-CoV-2 immunity in animal models.Cellular & molecular immunology · 2024
    Review
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

M D FahlbergTulane National Primate Research Center, Covington, LA, USA.ORCID 0000-0002-2597-7147
R V BlairTulane National Primate Research Center, Covington, LA, USA.
L A Doyle-MeyersTulane National Primate Research Center, Covington, LA, USA.
C C MidkiffTulane National Primate Research Center, Covington, LA, USA.
G ZenereTulane National Primate Research Center, Covington, LA, USA.
K E Russell-LodrigueTulane National Primate Research Center, Covington, LA, USA.ORCID 0000-0003-3719-0779
C J MonjureTulane National Primate Research Center, Covington, LA, USA.
E H HauptTulane National Primate Research Center, Covington, LA, USA.
T P PenneyTulane National Primate Research Center, Covington, LA, USA.
G LehmickeTulane National Primate Research Center, Covington, LA, USA.
B M ThreetonTulane National Primate Research Center, Covington, LA, USA.
N GoldenTulane National Primate Research Center, Covington, LA, USA.
P K DattaTulane National Primate Research Center, Covington, LA, USA.
C J RoyTulane National Primate Research Center, Covington, LA, USA.ORCID 0000-0002-1710-6974
R P BohmTulane National Primate Research Center, Covington, LA, USA.
N J ManessTulane National Primate Research Center, Covington, LA, USA.ORCID 0000-0002-9332-7891
T FischerTulane National Primate Research Center, Covington, LA, USA.ORCID 0000-0003-4859-3776
J RappaportTulane National Primate Research Center, Covington, LA, USA.
M VaccariTulane National Primate Research Center, Covington, LA, USA. mvaccari@tulane.edu.ORCID 0000-0002-4514-2681
Tulane University · US

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
NIH HHS P51 OD011104
6 · The paper itself

Abstract

Understanding SARS-CoV-2 associated immune pathology is crucial to develop pan-effective vaccines and treatments. Here we investigate the immune events from the acute state up to four weeks post SARS-CoV-2 infection, in non-human primates (NHP) with heterogeneous pulmonary pathology. We show a robust migration of CD16 expressing monocytes to the lungs occurring during the acute phase, and we describe two subsets of interstitial macrophages (HLA-DR

Indexed as

Disease Models, AnimalAcute DiseaseAnimalsCOVID-19CytokinesDisease ProgressionFemaleHumansLungMacaca mulattaMacrophagesMaleMonocytesNeutrophilsSARS-CoV-2Severity of Illness IndexCytokines

Identifiers

PMID33247138
PMCPMC7695721
OpenAlexW3110253728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.