ArticleNPJ biofilms and microbiomes2020
Attachment and antibiotic response of early-stage biofilms studied using resonant hyperspectral imaging.
Article in NPJ biofilms and microbiomes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
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- Deep Learning-Based Culture-Free Bacteria Detection in Urine Using Large-Volume Microscopy.Biosensors · 2024Article
- Reduced Graphene Oxide-Polydopamine-Gold Nanoparticles: A Ternary Nanocomposite-Based Electrochemical Genosensor for Rapid and EarlyBiosensors · 2023Article
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- Effect of Sub-Inhibitory Concentrations of Nitrofurantoin, Ciprofloxacin, and Trimethoprim on In Vitro Biofilm Formation in UropathogenicMedical sciences (Basel, Switzerland) · 2022Article
- Supporting the strategic pillars of translational research in biofilms.NPJ biofilms and microbiomes · 2022Article
- Multiplex Digital Quantification of β-Lactamase Genes in Antibiotic-Resistant Bacteria by Counting Gold Nanoparticle Labels on Silicon Microchips.Biosensors · 2022Article
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- Novel Micro-Nano Optoelectronic Biosensor for Label-Free Real-Time Biofilm Monitoring.Biosensors · 2021Article
- Bacteria Single-Cell and Photosensitizer Interaction Revealed by Quantitative Phase Imaging.International journal of molecular sciences · 2021Article
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Authors and funding
8 authors.
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Abstract
Many bacterial species readily develop biofilms that act as a protective matrix against external challenge, e.g., from antimicrobial treatment. Therefore, biofilms are often responsible for persistent and recurring infections. Established methods for studying biofilms are either destructive or focus on the biofilm's surface. A non-destructive method that is sensitive to the underside of the biofilm is highly desirable, as it allows studying the penetration of antibiotics through the film. Here, we demonstrate that the high surface sensitivity of resonant hyperspectral imaging provides this capability. The method allows us to monitor the early stages of Escherichia coli biofilm formation, cell attachment and microcolony formation, in-situ and in real-time. We study the response of the biofilm to a number of different antibiotics and verify our observations using confocal microscopy. Based on this ability to closely monitor the surface-bound cells, resonant hyperspectral imaging gives new insights into the antimicrobial resistance of biofilms.
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