Evidence map›Paper›PMID 33247100›Full record

ArticleNature communications2020

Feedforward prediction error signals during episodic memory retrieval.

Rafi U Haque, Sara K Inati, Allan I Levey, Kareem A Zaghloul

Abstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Prediction error and memory updating: Challenges ahead.Neuroscience and biobehavioral reviews · 2025
    Article
  2. Article
  3. Review
  4. Article
  5. Prediction errors disrupt hippocampal representations and update episodic memories.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  6. The hippocampus as the switchboard between perception and memory.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rafi U HaqueSurgical Neurology Branch, NINDS, National Institutes of Health, Bethesda, MD, 20892, USA.
Sara K InatiOffice of the Clinical Director, NINDS, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID 0000-0002-7587-5085
Allan I LeveyDepartment of Neurology, Emory University, Atlanta, GA, 30322, USA.ORCID 0000-0002-3153-502X
Kareem A ZaghloulSurgical Neurology Branch, NINDS, National Institutes of Health, Bethesda, MD, 20892, USA. kareem.zaghloul@nih.gov.ORCID 0000-0001-8575-3578

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3M
NIGMS NIH HHS T32 GM008169
6 · The paper itself

Abstract

Our memories enable us to form expectations for our future experiences, yet the precise neural mechanisms underlying how we compare any experience to our memory remain unknown. Here, using intracranial EEG recordings, we show that episodic memories formed after a single visual experience establish expectations for future experience within neocortical-medial temporal lobe circuits. When subsequent experiences violate these expectations, we find a 80-120 Hz prediction error signal that emerges in both visual association areas and the medial temporal lobe. Critically, this error signal emerges in visual association areas first and then propagates to the medial temporal lobe. This error signal is accompanied by alpha coherence between the two regions. Our data therefore suggest that internal models formed from episodic memories are generated throughout the visual hierarchy after just a single exposure, and that these internal models are then used for comparison with future experiences.

Indexed as

Memory, EpisodicAdultAlpha RhythmElectrodesFemaleFixation, OcularHumansMaleMental RecallModels, NeurologicalPhotic StimulationSpace PerceptionTask Performance and AnalysisTemporal LobeTime FactorsVisual Cortex

Identifiers

PMID33247100
PMCPMC7699639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.