Evidence map›Paper›PMID 33247028›Full record

Observational studyBMJ open2020

Clinical evaluation of pharmacists' interventions on multidisciplinary lung transplant outpatients' management: results of a 7-year observational study.

Marion Duwez, Sébastien Chanoine, Marion Lepelley, Thi Ha Vo, Hélène Pluchart, Roseline Mazet, Benoit Allenet, Christophe Pison, Amandine Briault, Christelle Saint-Raymond and 3 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. The expanded role of the transplant pharmacist: A 10-year follow-up.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023
    Article
  13. Observational
  14. Article
  15. Observational
  16. Advances in the management of pulmonary arterial hypertension.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2021
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Marion DuwezPharmacy, CHUGA, Grenoble, France marion.duwez@gmail.com.ORCID 0000-0002-0776-130X
Sébastien ChanoinePharmacy, CHUGA, Grenoble, France.ORCID 0000-0001-7708-9777
Marion LepelleyPublic Health Department, CHUGA, Grenoble, France.ORCID 0000-0002-8506-8228
Thi Ha VoPharmacy Faculty, Pham Ngoc Thach Medical University, Hochiminh, Viet Nam.ORCID 0000-0001-6170-0957
Hélène PluchartPharmacy, CHUGA, Grenoble, France.ORCID 0000-0003-2438-6481
Roseline MazetPharmacy, CHUGA, Grenoble, France.ORCID 0000-0002-1841-6691
Benoit AllenetPharmacy, CHUGA, Grenoble, France.ORCID 0000-0002-9989-5101
Christophe PisonService Hospitalier Universitaire Pneumologie Physiologie, CHUGA, Grenoble, France.ORCID 0000-0002-2152-6461
Amandine BriaultService Hospitalier Universitaire Pneumologie Physiologie, CHUGA, Grenoble, France.
Christelle Saint-RaymondService Hospitalier Universitaire Pneumologie Physiologie, CHUGA, Grenoble, France.
Boubou CamaraService Hospitalier Universitaire Pneumologie Physiologie, CHUGA, Grenoble, France.ORCID 0000-0001-8880-1803
Johanna ClaustreService Hospitalier Universitaire Pneumologie Physiologie, CHUGA, Grenoble, France.ORCID 0000-0003-3788-0892
Pierrick BedouchPharmacy, CHUGA, Grenoble, France.ORCID 0000-0003-2245-0160
Centre Hospitalier Universitaire de Grenoble · FRCentre National de la Recherche Scientifique · FRPham Ngoc Thach University of Medicine · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesLung transplant (LT) recipients require multidisciplinary care because of the complexity of therapeutic management. Pharmacists are able to detect drug-related problems and provide recommendations to physicians through pharmacists' interventions (PIs). We aimed at assessing the clinical impact of PIs on therapeutic management in LT outpatients.

designData were collected prospectively from an LT recipients cohort during 7 years. A multidisciplinary committee assessed retrospectively the clinical impact of accepted PIs.

settingFrench University Hospital.

participantsLT outpatients followed from 2009 to 2015. PRIMARY OUTCOME MEASURES: Clinical impact of PIs performed by pharmacists using the CLEO tool and the Pareto chart.

results1449 PIs led to a change in patient therapeutic management and were mainly related to wrong dosage (39.6%) and untreated indication (19.6%). The clinical impact of PIs was 'avoids fatality', 'major' and 'moderate', in 0.1%, 7.0% and 57.9%, respectively. Immunosuppressants, antimycotics for systemic use and antithrombotic agents had the greatest clinical impact according to the Pareto chart. PIs related to drug-drug interactions (10%) mainly had a moderate and major clinical impact (82.3%, p<0.0001).

conclusionClinical pharmacists play a key role for detecting drug-related problems mostly leading to a change in therapeutic management among LT outpatients. Our study provides a new insight to analyse the clinical impact of PIs in order to target PIs which have most value and contribute to patient care through interdisciplinary approach.

Indexed as

PharmacistsAdolescentAdultChildFemaleHumansLungLung TransplantationMaleMedication ErrorsMiddle AgedOutpatientsPharmacy Service, HospitalProfessional RoleRetrospective StudiesYoung Adultrespiratory medicine (see thoracic medicine)therapeuticstransplant medicine

Identifiers

PMID33247028
PMCPMC7703423
OpenAlexW3107716281

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.