Evidence map›Paper›PMID 33247014›Full record

Observational studyBMJ open2020

International observational atopic dermatitis cohort to follow natural history and treatment course: TARGET-DERM AD study design and rationale.

Katrina Abuabara, Jonathan I Silverberg, Eric L Simpson, Amy S Paller, Lawrence F Eichenfield, Robert Bissonnette, James Krueger, John E Harris, Laura Dalfonso, Stephanie E Watkins and 3 more

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03661866 (A Longitudinal Observational Study of Patients Undergoing Therapy for Immune-Mediated Inflammatory Skin Conditions), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03661866 active not recruitingnot on this map

A Longitudinal Observational Study of Patients Undergoing Therapy for Immune-Mediated Inflammatory Skin Conditions

Typeobservational_patient_registrySponsorTarget PharmaSolutions, Inc.Ran2018 to 2050Enrolled15,000ConditionsAtopic Dermatitis, Alopecia Areata, Hidradenitis Suppurativa, Vitiligo
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Katrina AbuabaraDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA katrina.abuabara@ucsf.edu.ORCID 0000-0002-7736-6946
Jonathan I SilverbergDepartment of Dermatology, George Washington University, Washington, DC, USA.ORCID 0000-0003-3686-7805
Eric L SimpsonDepartment of Dermatology, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0002-8793-7087
Amy S PallerDepartment of Dermatology, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0001-6187-6549
Lawrence F EichenfieldDepartment of Dermatology, University of California, San Diego School, La Jolla, California, USA.ORCID 0000-0002-2760-0474
Robert BissonnetteInnovaderm Research, Montreal, Quebec, Canada.ORCID 0000-0001-5927-6587
James KruegerDepartment of Immunology, Virology and Microbiology, Rockefeller Institute for Medical Research, New York, New York, USA.ORCID 0000-0002-3775-1778
John E HarrisDepartment of Dermatology, University of Massachusetts Medical School, Worcester, MA, USA.ORCID 0000-0002-7815-6430
Laura DalfonsoClinical Operations, TARGET PharmaSolutions, Durham, North Carolina, USA.ORCID 0000-0001-5442-9433
Stephanie E WatkinsScientific and Medical Affairs, TARGET PharmaSolutions, Durham, North Carolina, USA.
Julie M CrawfordScientific and Medical Affairs, TARGET PharmaSolutions, Durham, North Carolina, USA.ORCID 0000-0001-8976-8558
D ThaçiComprehensive Center for Inflammation Medicine, University of Lubeck, Lubeck, Schleswig-Holstein, Germany.ORCID 0000-0001-8513-550X
Emma Guttman-YasskyDepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-9363-324X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAs new topical and systemic treatments become available for atopic dermatitis (AD), there is a need to understand how treatments are being used in routine clinical practice, their comparative effectiveness and their long-term safety in diverse clinical settings. METHODS AND ANALYSIS: The TARGET-DERM AD cohort is a longitudinal, observational study of patients with AD of all ages, designed to provide practical information on long-term effectiveness and safety unobtainable in traditional registration trials. Patients with physician-diagnosed AD receiving prescription treatment (topical or systemic) will be enrolled at academic and community clinical centres. Up to 3 years of retrospective medical records, 5 years of prospective medical records, and optional biological samples and patient-reported outcomes will be collected. The primary aims include characterisation of AD treatment regimens, evaluation of response to therapy, and description of adverse events. ETHICS AND DISSEMINATION: TARGET-DERM has been approved by a central IRB (Copernicus Group IRB, 5000 Centregreen Way Suite 200, Cary, North Carolina 27513) as well as local and institutional IRBs. No additional Ethics Committee reviews. Results will be reviewed by a publications committee and submitted to peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT03661866, pre-results.

Indexed as

Dermatitis, AtopicHumansNorth CarolinaProspective StudiesRetrospective Studieseczemamedical historystatistics & research methodstherapeutics

Identifiers

PMID33247014
PMCPMC7703415

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.