Evidence map›Paper›PMID 33246992›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2020

Pulmonary alveolar microlithiasis.

Patrick Kosciuk, Cristopher Meyer, Kathryn A Wikenheiser-Brokamp, Francis X McCormack

Open access · diamondAbstract readReview
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
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  6. Article
  7. Soft tissue calcifications in chronic kidney disease-beyond the vasculature.Pflugers Archiv : European journal of physiology · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Exploring the silent storm.Qatar medical journal · 2024
    Article
  14. Article
  15. Pulmonary alveolar microlithiasis: a rare case report from Syria.Annals of medicine and surgery (2012) · 2023
    Article
  16. Article
  17. The world of rare interstitial lung diseases.European respiratory review : an official journal of the European Respiratory Society · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Patrick KosciukDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati, Cincinnati, OH, USA.
Cristopher MeyerDivision of Radiology, University of Wisconsin, Madison, WI, USA.
Kathryn A Wikenheiser-BrokampDivision of Pathology & Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Francis X McCormackDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati, Cincinnati, OH, USA frank.mccormack@uc.edu.ORCID https://orcid.org/0000-0001-7168-9464
University of Cincinnati · USCincinnati Children's Hospital Medical Center · USUniversity of Wisconsin–Madison · US

Funding

Pathogenesis-Driven Therapeutic Development for Pulmonary Alveolar MicrolithiasisR01HL127455 · NHLBI · UNIVERSITY OF CINCINNATI · PI MCCORMACK, FRANCIS XAVIER · 2015 to 2018
$1.6M
NHLBI NIH HHS R01 HL127455
6 · The paper itself

Abstract

Pulmonary alveolar microlithiasis (PAM) is a fascinating rare lung disease that is associated with the accumulation of hydroxyapatite microliths within the lumen of the alveolar spaces. In most patients, PAM is discovered incidentally on radiographs performed for other purposes, and the typical disease course is characterised by slowly progressive respiratory insufficiency over decades. Recent genetic analyses that have revealed that the deficiency of the sodium-phosphate cotransporter NPT2B is the cause of PAM have enabled the development of powerful animal models that inform our approach to disease management and treatment. Here we review the epidemiology and molecular pathophysiology of PAM, as well as the diagnostic approach, clinical manifestations, radiographic and pathologic features, and clinical management of the disease. Although there are no proven treatments for PAM, progress in our understanding of disease pathogenesis is providing insights that suggest strategies for trials.

Indexed as

CalcinosisLung DiseasesAnimalsGenetic Diseases, InbornHumansLungPulmonary AlveoliSodium-Phosphate Cotransporter Proteins, Type IIbSodium-Phosphate Cotransporter Proteins, Type IIb

Identifiers

PMID33246992
PMCPMC9488654
OpenAlexW3106827664

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.