Evidence map›Paper›PMID 33246964›Full record

ArticleScience advances2020

Retracing the evolutionary emergence of thymopoiesis.

Jeremy B Swann, Anja Nusser, Ryo Morimoto, Daisuke Nagakubo, Thomas Boehm

Abstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Animals have expanded the evolutionary legacy of unicellular ancestors in blood cells.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. LampreyProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Informed clinical decisions by outfoxing human FOXN1 variants.The Journal of allergy and clinical immunology · 2025
    Review
  5. Article
  6. Assembling the thymus medulla: Development and function of epithelial cell heterogeneity.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Article
  7. Hematopoietic Stem Cells and the Immune System in Development and Aging.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jeremy B SwannDepartment of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.ORCID 0000-0003-2168-8994
Anja NusserDepartment of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.ORCID 0000-0002-8157-0560
Ryo MorimotoDepartment of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.ORCID 0000-0002-5497-4666
Daisuke NagakuboDepartment of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.ORCID 0000-0003-1213-1246
Thomas BoehmDepartment of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany. boehm@ie-freiburg.mpg.de.ORCID 0000-0001-5172-7478

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The onset of lymphocyte development in the vertebrate primordial thymus, about 500 million years ago, represents one of the foundational events of the emerging adaptive immune system. Here, we retrace the evolutionary trajectory of thymopoiesis, from early vertebrates to mammals, guided by members of the

Indexed as

LymphopoiesisT-LymphocytesAnimalsB-LymphocytesMammalsMiceMice, TransgenicPhylogenyVertebrates

Identifiers

PMID33246964
PMCPMC7695478

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.