ArticleBMC geriatrics2020
Mild behavioral impairment is related to frailty in non-dementia older adults: a cross-sectional study.
Article in BMC geriatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Risk factors of mild behavioral impairment: a systematic review.Frontiers in psychology · 2025Pooled it
- Phenotyping of mild behavioral impairment domains in multi-regional dementia-free older adults of Chinese ethnicity: impulse dyscontrol as the leading domain.The journal of prevention of Alzheimer's disease · 2026Article
- Mild behavioral impairment is longitudinally associated with frailty in very old adults with MCI: insights from COGFRAIL.Aging clinical and experimental research · 2026Article
- Reframing Dementia Prevention Strategies Aligned with the WHO Global Action Plan: A Structured Narrative Review Focusing on Mild Behavioral Impairment.Neurology international · 2026Review
- Correlates of mild behavioural impairment in older adults: a scoping review.BMC geriatrics · 2025Article
- Correlation between mild behavioral impairment and peripheral blood biomarkers in patients with mild cognitive impairment.World journal of psychiatry · 2025Article
- Assessing Social Interaction and Loneliness and Their Association With Frailty Among Older Adults With Subjective Cognitive Decline or Mild Cognitive Impairment: Ecological Momentary Assessment Approach.JMIR mHealth and uHealth · 2025Article
- Article
- Vascular risk factor associations with subjective cognitive decline and mild behavioural impairment.Brain communications · 2025Article
- Relationship between Loneliness and Mild Behavioral Impairment: Validation of the Japanese Version of the MBI Checklist and a Cross-Sectional Study.Journal of Alzheimer's disease : JAD · 2024Article
- Parkinson's Disease, SARS-CoV-2, and Frailty: Is There a Vicious Cycle Related to Hypovitaminosis D?Brain sciences · 2023Review
- Neuroimaging of mild behavioral impairment: A systematic review.PCN reports : psychiatry and clinical neurosciences · 2023Review
- A review of current evidence for mild behavioral impairment as an early potential novel marker of Alzheimer's disease.Frontiers in psychiatry · 2023Review
- Mild behavioral impairment is associated with progression to Alzheimer's disease: A clinicopathological study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Mild behavioral impairment: measurement and clinical correlates of a novel marker of preclinical Alzheimer's disease.Alzheimer's research & therapy · 2022Review
- The Frailty Puzzle: Searching for Immortality or for Knowledge Survival?Frontiers in cellular neuroscience · 2022Review
- Depression and Dementia in Older Adults: A Neuropsychological Review.Aging and disease · 2021Review
- Prevalence of cognitive impairment in Chinese older inpatients and its relationship with 1-year adverse health outcomes: a multi-center cohort study.BMC geriatrics · 2021Article
- White matter hyperintensities and mild behavioral impairment: Findings from the MEMENTO cohort study.Cerebral circulation - cognition and behavior · 2021Article
- Late-life onset psychotic symptoms and incident cognitive impairment in people without dementia: Modification by genetic risk for Alzheimer's disease.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundFrailty and cognitive decline are highly prevalent among older adults. However, the relationship between frailty and mild behavioral impairment (MBI), a dementia risk syndrome characterized by later-life emergence of persistent neuropsychiatric symptoms, has yet to be elucidated. We aimed to evaluate the associations between MBI and frailty in older adults without dementia.
methodsIn this cross-sectional study, a consecutive series of 137 older adults without dementia in the Anti-Aging Study, recruited from primary care clinics, were enrolled. Frailty was estimated using the Fried phenotype. MBI was evaluated by the Mild Behavioral Impairment Checklist (MBI-C) at a cut-off point of > 8. Cognition was assessed with the Chinese versions of the Montreal Cognitive Assessment (MoCA-BC) and Mini-mental State Examination (MMSE). Multivariable logistic regression was performed to estimate the relationship between MBI and objective cognition with frailty status.
resultsAt baseline, 30.7% of the older adults had frailty and 18.2% had MBI (MBI+ status). Multivariable logistic regression analysis demonstrated that compared to those without MBI (MBI- status), MBI+ was more likely to have frailty (odds ratio [OR] = 7.44, 95% CI = 1.49-37.21, p = 0.02). Frailty and MBI were both significantly associated with both MMSE and MoCA-BC score (p < 0.05).
conclusionsBoth frailty and MBI status were associated with higher odds of cognitive impairment. MBI was significantly associated with an increased risk of having frailty in the absence of dementia. This association merits further study to identify potential strategies for the early detection, prevention and therapeutic intervention of frailty.
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