ArticleRheumatology (Oxford, England)2021
Towards developing diagnostic criteria for early knee osteoarthritis: data from the CHECK study.
Article in Rheumatology (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Effects of Wuqinxi on joint function, muscle strength, and balance function in patients with knee osteoarthritis: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Risk Assessment for Hip and Knee Osteoarthritis Using Polygenic Risk Scores.Arthritis & rheumatology (Hoboken, N.J.) · 2022Pooled it
- Effect of Wu Qin Xi exercises on pain and function in people with knee osteoarthritis: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Knee Crepitus and Osteoarthritis Features in Young Adults Following Traumatic Knee Injury.Arthritis care & research · 2026Article
- Development and validation of a simple nomogram for predicting knee osteoarthritis using movement evoked pain in a community setting.Scientific reports · 2026Article
- Effects of celecoxib combined with duloxetine on chronic pain, depression, and anxiety in patients with knee osteoarthritis.World journal of psychiatry · 2026Article
- AIDS patients suffer higher risk of advanced knee osteoarthritis progression due to lopinavir-induced Zmpste24 inhibition.Bone research · 2025Article
- Osteoarthritis.Nature reviews. Disease primers · 2025Review
- Comparison of definitions of early knee osteoarthritis for likelihood of progression at 2-year and 5-year follow-up: the Multicenter Osteoarthritis Study.Annals of the rheumatic diseases · 2025Article
- Planned or recent first consultation with the general practitioner for knee complaints: Is it indicative of early-stage knee osteoarthritis?Osteoarthritis and cartilage open · 2024Article
- Two-year clinical follow-up enhances the diagnosis of early-stage hip osteoarthritis: data from check cohort.RMD open · 2024Article
- Article
- Imaging of early-stage osteoarthritis: the needs and challenges for diagnosis and classification.Skeletal radiology · 2023Article
- Quadriceps Strength, Postural Stability, and Pain Mediation in Bilateral Knee Osteoarthritis: A Comparative Analysis with Healthy Controls.Diagnostics (Basel, Switzerland) · 2023Article
- A scoping review of how early-stage knee osteoarthritis has been defined.Osteoarthritis and cartilage · 2023Article
- Soluble and EV-Associated Diagnostic and Prognostic Biomarkers in Knee Osteoarthritis Pathology and Detection.Life (Basel, Switzerland) · 2023Review
- Cartilage Oligomeric Matrix Protein, Diseases, and Therapeutic Opportunities.International journal of molecular sciences · 2022Review
- Diagnostic criteria for early hip osteoarthritis: first steps, based on the CHECK study.Rheumatology (Oxford, England) · 2021Article
- Early-stage symptomatic osteoarthritis of the knee - time for action.Nature reviews. Rheumatology · 2021Review
- Diagnosis of early stage knee osteoarthritis based on early clinical course: data from the CHECK cohort.Arthritis research & therapy · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThere is a general consensus that a shift in focus towards early diagnosis and treatment of knee OA is warranted. However, there are no validated and widely accepted diagnostic criteria for early knee OA available. The current study aimed to take the first steps towards developing diagnostic criteria for early knee OA.
methodsData of 761 individuals with 1185 symptomatic knees at baseline were selected from the CHECK study. For CHECK, individuals with pain/stiffness of the knee, aged 45-65 years, who had no prior consultation or a first consultation with the general practitioner for these symptoms in the past 6 months were recruited and followed for 10 years. A group of 36 experts (17 general practitioners and 19 secondary care physicians) evaluated the medical records in pairs to diagnose the presence of clinically relevant knee OA 5-10 years after enrolment. A backward selection methods was used to create predictive models based on pre-defined baseline factors from history taking, physical examination, radiography and blood testing, using the experts' diagnoses as gold standard outcome.
resultsPrevalence of clinically relevant knee OA during follow-up was 37%. Created models contained 7-11 baseline factors and obtained an area under the curve between 0.746 (0.002) and 0.764 (0.002).
conclusionThe obtained diagnostic models for early knee OA had 'fair' predictive ability in individuals presenting with knee pain in primary care. Further modelling and validation of the identified predictive factors is required to obtain clinically feasible and relevant diagnostic criteria for early knee OA.
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