Evidence map›Paper›PMID 33246227›Full record

ArticleMedical image analysis2021

Capsules for biomedical image segmentation.

Rodney LaLonde, Ziyue Xu, Ismail Irmakci, Sanjay Jain, Ulas Bagci

Abstract read
In one paragraph

Article in Medical image analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Attention-gated 3D CapsNet for robust hippocampal segmentation.Journal of medical imaging (Bellingham, Wash.) · 2024
    Article
  7. Review
  8. Review
  9. 3D Capsule Networks for Brain Image Segmentation.AJNR. American journal of neuroradiology · 2023
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Multi-Contrast MRI Segmentation Trained on Synthetic Images.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2022
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rodney LaLondeCenter for Research in Computer Vision (CRCV), University of Central Florida (UCF), Orlando, FL.
Ziyue XuNvidia, Bethesda, MD USA.
Ismail IrmakciEge University, Izmir, Turkey.
Sanjay JainJohns Hopkins University, Baltimore, MD US State.
Ulas BagciCenter for Research in Computer Vision (CRCV), University of Central Florida (UCF), Orlando, FL. Electronic address: bagci@crcv.ucf.edu.

Funding

Preclinical modeling to study Tuberculous MeningitisR01AI145435 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$4.0M
Measuring Intralesional Drug Exposures in Cavitary TB using Noninvasive In Vivo PET ImagingR01AI153349 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$3.8M
Novel Imaging Tracers for Rapid and Noninvasive Assessment of Bacterial InfectionR01EB020539 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2014 to 2018
$3.6M
Cyst-X: Interpretable Deep Learning Based Risk Stratification of Pancreatic Cystic TumorsR01CA246704 · NCI · UNIVERSITY OF CENTRAL FLORIDA · PI BAGCI, ULAS · 2020 to 2024
$2.4M
Radiologist-Centered Artificial Intelligence (RCAI) for Lung Cancer Screening and DiagnosisR01CA240639 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BAGCI, ULAS · 2020 to 2024
$2.0M
NCI NIH HHS R01 CA240639NCI NIH HHS R01 CA246704NIAID NIH HHS R01 AI145435NIAID NIH HHS R01 AI153349NIBIB NIH HHS R01 EB020539
6 · The paper itself

Abstract

Our work expands the use of capsule networks to the task of object segmentation for the first time in the literature. This is made possible via the introduction of locally-constrained routing and transformation matrix sharing, which reduces the parameter/memory burden and allows for the segmentation of objects at large resolutions. To compensate for the loss of global information in constraining the routing, we propose the concept of "deconvolutional" capsules to create a deep encoder-decoder style network, called SegCaps. We extend the masked reconstruction regularization to the task of segmentation and perform thorough ablation experiments on each component of our method. The proposed convolutional-deconvolutional capsule network, SegCaps, shows state-of-the-art results while using a fraction of the parameters of popular segmentation networks. To validate our proposed method, we perform experiments segmenting pathological lungs from clinical and pre-clinical thoracic computed tomography (CT) scans and segmenting muscle and adipose (fat) tissue from magnetic resonance imaging (MRI) scans of human subjects' thighs. Notably, our experiments in lung segmentation represent the largest-scale study in pathological lung segmentation in the literature, where we conduct experiments across five extremely challenging datasets, containing both clinical and pre-clinical subjects, and nearly 2000 computed-tomography scans. Our newly developed segmentation platform outperforms other methods across all datasets while utilizing less than 5% of the parameters in the popular U-Net for biomedical image segmentation. Further, we demonstrate capsules' ability to generalize to unseen handling of rotations/reflections on natural images.

Indexed as

Image Processing, Computer-AssistedNeural Networks, ComputerCapsulesHumansMagnetic Resonance ImagingTomography, X-Ray ComputedCapsulesCapsule networkLung segmentationPre-clinical imagingThigh MRI segmentation

Identifiers

PMID33246227
PMCPMC7944580

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.