Evidence map›Paper›PMID 33245727›Full record

ArticleOncotarget2020

Immune profiling of the bone marrow microenvironment in patients with high-risk localized prostate cancer.

Erika Heninger, Nan Sethakorn, David Kosoff, Peiman Hematti, Morgan D Kuczler, Kenneth J Pienta, Joshua M Lang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Erika HeningerUniversity of Wisconsin Carbone Cancer Center, Madison, WI, USA.
Nan SethakornDepartment of Oncology, University of Wisconsin, Madison, WI, USA.
David KosoffDepartment of Medicine, University of Wisconsin, Madison, WI, USA.
Peiman HemattiUniversity of Wisconsin Carbone Cancer Center, Madison, WI, USA.
Morgan D KuczlerDepartment of Urology, The James Buchanan Brady Urological Institute, Baltimore, MD, USA.
Kenneth J PientaDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
Joshua M LangUniversity of Wisconsin Carbone Cancer Center, Madison, WI, USA.
University of Wisconsin Carbone Cancer Center · USUniversity of Wisconsin–Madison · USSidney Kimmel Comprehensive Cancer Center · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
RESEARCH TRAINING IN HEMATOLOGYT32HL007899 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Jane Ellen Churpek · 1998 to 2026
$8.2M
NCI NIH HHS P30 CA014520NHLBI NIH HHS T32 HL007899
6 · The paper itself

Abstract

Bone marrow (BM) is a primary metastatic site in prostate cancer (PC) and bone invasion is considered incurable. T cell-mediated immune surveillance is essential in controlling both tumorigenesis and initiation of metastases. Beside tropism, dissemination of PC cells to the BM may be facilitated by defects in BM immune homeostasis predisposing this niche to colonization. To evaluate the BM immune microenvironment in locally advanced, non-metastatic PC, we performed flow cytometry analysis of myeloid and lymphoid subsets in BM aspirates and peripheral blood collected during prostatectomy. Healthy BM aspirates served to establish a reference range for comparison. We found alterations in BM immune composition of PC patients, including an increased CD4/CD8 ratio, enrichment of CD4

Indexed as

bone marrowimmune landscapeimmune profilingprostate cancertumor microenvironment

Identifiers

PMID33245727
PMCPMC7679037
OpenAlexW3102571857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.