Evidence map›Paper›PMID 33245712›Full record

ReviewMedical science monitor : international medical journal of experimental and clinical research2020

Role of Exosomes in the Progression, Diagnosis, and Treatment of Gliomas.

Ji Shi, Ye Zhang, Bing Yao, Peixin Sun, Yuanyuan Hao, Haozhe Piao, Xi Zhao

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Medical science monitor : international medical journal of experimental and clinical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Review
  3. Biologically Guided Gamma Knife Dose Painting for Recurrent High-Grade Gliomas: A Retrospective Study Using Functional MRI Techniques.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
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  5. Review
  6. Astrocyte involvement in metabolic regulation and disease.Trends in endocrinology and metabolism: TEM · 2025
    Review
  7. Article
  8. Article
  9. Impact of hypoxia on the molecular content of glioblastoma-derived exosomes.Extracellular vesicles and circulating nucleic acids · 2024
    Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ji ShiDepartment of Neurosurgery, Cancer Hospital of China Medical University, Shenyang, Liaoning, China (mainland).
Ye ZhangDepartment of Neurosurgery, Cancer Hospital of China Medical University, Shenyang, Liaoning, China (mainland).
Bing YaoDepartment of Neurosurgery, Cancer Hospital of China Medical University, Shenyang, Liaoning, China (mainland).
Peixin SunDepartment of Neurosurgery, Cancer Hospital of China Medical University, Shenyang, Liaoning, China (mainland).
Yuanyuan HaoDepartment of Neurosurgery, Cancer Hospital of China Medical University, Shenyang, Liaoning, China (mainland).
Haozhe PiaoDepartment of Neurosurgery, Cancer Hospital of China Medical University, Shenyang, Liaoning, China (mainland).
Xi ZhaoDepartment of Anesthesia, Cancer Hospital of China Medical University, Shenyang, Liaoning, China (mainland).
China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gliomas are the most common primary malignant brain tumors associated with a low survival rate. Even after surgery, radiotherapy, and chemotherapy, gliomas still have a poor prognosis. Extracellular vesicles are a heterogeneous group of cell-derived membranous structures. Exosomes are a type of extracellular vesicles, their size ranges from 30 nm to 100 nm. Recent studies have proved that glioma cells could release numerous exosomes; therefore, exosomes have gained increasing attention in glioma-related research. Recent studies have confirmed the importance of extracellular vesicles, particularly exosomes, in the development of brain tumors, including gliomas. Exosomes mediate intercellular communication in the tumor microenvironment by transporting biomolecules (proteins, lipids, deoxyribonucleic acid, and ribonucleic acid); thereby playing a prominent role in tumor proliferation, differentiation, metastasis, and resistance to chemotherapy or radiation. Given their nanoscale size, exosomes can traverse the blood-brain barrier and promote tumor progression by modifying the tumor microenvironment. Based on their structural and functional characteristics, exosomes are demonstrating their value not only as diagnostic and prognostic markers, but also as tools in therapies specifically targeting glioma cells. Therefore, exosomes are a promising therapeutic target for the diagnosis, prognosis, and treatment of malignant gliomas. More research will be needed before exosomes can be used in clinical applications. Here, we describe the exosomes, their morphology, and their roles in the diagnosis and progression of gliomas. In addition, we discuss the potential of exosomes as a therapeutic target/drug delivery system for patients with gliomas.

Indexed as

Disease ProgressionBrain NeoplasmsExosomesGliomaHumansImmunotherapyPrognosis

Identifiers

PMID33245712
PMCPMC7706139
OpenAlexW3090952712

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.