ArticleThe Journal of pathology2020
Cathelicidin-related antimicrobial peptide alleviates alcoholic liver disease through inhibiting inflammasome activation.
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Article in The Journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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23citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 9% of its field
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Analysis of Antimicrobial Peptide Expression Under Acute and Chronic Alcohol Exposure: A Cross-Sectional Study and a Systematic Review of the Literature.International journal of molecular sciences · 2026Pooled it
- Influence of Alcohol on the Intestinal Immune System.Alcohol research : current reviews · 2025Pooled it
- LL-37: Biological Mechanisms and Emerging Therapeutic Applications in Intestinal Disease.Immunity, inflammation and disease · 2026Review
- Cathelicidin LL-37-ApoB-100 interaction promotes LDL clearance and attenuates cholesterol accumulation in the liver.Science China. Life sciences · 2026Article
- Neutrophil-T cell cross talk in noninfectious liver diseases.American journal of physiology. Gastrointestinal and liver physiology · 2026Review
- Hepatoprotective Effect ofFood science & nutrition · 2026Article
- IL-6 trans-Signaling Regulates Neutrophilic Inflammation in Alcohol-Associated Hepatitis.The American journal of pathology · 2026Article
- Comprehensive single-cell analysis deciphered the immunoregulatory mechanism of TPPU in alleviating sepsis-related acute liver injury.Journal of advanced research · 2025Article
- Gut-X axis.iMeta · 2025Review
- Hyperuricemia-induced complications: dysfunctional macrophages serve as a potential bridge.Frontiers in immunology · 2025Review
- Gut-liver axis: Recent concepts in pathophysiology in alcohol-associated liver disease.Hepatology (Baltimore, Md.) · 2024Review
- Review
- Alterations in metabolome and microbiome: new clues on cathelicidin-related antimicrobial peptide alleviates acute ulcerative colitis.Frontiers in microbiology · 2024Article
- Significant gut microbiota related to patterns of drinking and alcohol relapse in patients with alcoholic hepatitis undergoing stool transplant or corticosteroid therapy.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Article
- Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease.Journal of translational medicine · 2023Review
- Mice lacking α4 nicotinic acetylcholine receptors are protected against alcohol-associated liver injury.Alcoholism, clinical and experimental research · 2022Article
- Coffee reduces the risk of hepatocellular carcinoma probably through inhibition of NLRP3 inflammasome activation by caffeine.Frontiers in oncology · 2022Article
- Milk Fat Globule Membrane Attenuates Acute Colitis and Secondary Liver Injury by Improving the Mucus Barrier and Regulating the Gut Microbiota.Frontiers in immunology · 2022Article
- Article
- Human Beta Defensin 2 Ameliorated Alcohol-Associated Liver Disease in Mice.Frontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 2 countries.
Fengyuan LiDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.
Cuiqing ZhaoDepartment of Medicine, University of Louisville, Louisville, KY, USA.
Tuo ShaoDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.
Yunhuan LiuDepartment of Medicine, University of Louisville, Louisville, KY, USA.
Zelin GuDepartment of Medicine, University of Louisville, Louisville, KY, USA.
Mengwei JiangDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.
Huimin LiDepartment of Medicine, University of Louisville, Louisville, KY, USA.
Lihua ZhangDepartment of Medicine, University of Louisville, Louisville, KY, USA.
Patrick M GillevetDepartment of Biology, George Mason University, Manassas, VA, USA.
Puneet PuriSection of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, VA, USA.
Zhong-Bin DengDepartment of Medicine, University of Louisville, Louisville, KY, USA.
Shao-Yu ChenDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.
Shirish BarveDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.
Leila GobejishviliDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.
Vatsalya VatsalyaDepartment of Medicine, University of Louisville, Louisville, KY, USA.
Craig J McClainDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.
Wenke FengDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.ORCID 0000-0001-5456-5347
University of Louisville · USGeorge Mason University · USJiujiang University · CNVirginia Commonwealth University · US
Funding
Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI HOOD, JOSHUA L. · 2016 to 2025
$24.1MThe Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN · 2016 to 2026
$17.9MClinical Resources for Alcoholic Hepatitis InvestigationsR24AA025017 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI ZHAOLI SUN · 2016 to 2026
$6.6MNovel Therapies for Alcoholic HepatitisU01AA021893 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI MCCLAIN, CRAIG J., MCCULLOUGH, ARTHUR JOSEPH · 2012 to 2017
$6.0MMechanisms of Probiotics in Alcoholic Liver DiseaseR01AA023190 · NIAAA · UNIVERSITY OF LOUISVILLE · PI FENG, WENKE · 2015 to 2024
$3.5MIntegrated therapies for alcohol use and ALD (ITAALD) Network -UofL Clinical CenterU01AA026980 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN, Ashwani K Singal · 2018 to 2026
$2.9MCSN8 regulation of S1P-enriched extracellular vesicles to modulate NAFLD by gut-liver axisR01DK115406 · NIDDK · UNIVERSITY OF LOUISVILLE · PI DENG, ZHONG-BIN · 2018 to 2022
$2.0MRole of exosomes in the coordinated migration of neural crest cells and placodes and ethanol-induced teratogenesisR01AA028435 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CHEN, SHAO-YU · 2020 to 2024
$1.8MRole of microRNAs in Ethanol-induced Apoptosis and TeratogenesisR01AA021434 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CHEN, SHAO-YU · 2013 to 2017
$1.7MOxidized Metabolites of Linoleic Acid in Alcohol-induced Liver InjuryU01AA022489 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FELDSTEIN, ARIEL, MCCLAIN, CRAIG J. · 2014 to 2018
$1.7MRole of Siah1 in ethanol-induced apoptosis and teratogenesisR01AA020265 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CHEN, SHAO-YU · 2012 to 2016
$1.7MMechanisms for alcohol induced gut barrier dysfunction in ALDR01AA023681 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2014 to 2018
$1.6MBLRD VA I01 BX002996NIAAA NIH HHS K23 AA021179NIAAA NIH HHS P50 AA024337NIAAA NIH HHS R01 AA020265NIAAA NIH HHS R01 AA021434NIAAA NIH HHS R01 AA023190NIAAA NIH HHS R01 AA023681NIAAA NIH HHS R01 AA028435NIAAA NIH HHS R21 AA020848NIAAA NIH HHS R21 AA022416NIAAA NIH HHS R21 AA025724NIAAA NIH HHS R24 AA025017NIAAA NIH HHS U01 AA021893NIAAA NIH HHS U01 AA021901NIAAA NIH HHS U01 AA022489NIAAA NIH HHS U01 AA026936NIAAA NIH HHS U01 AA026980NIAID NIH HHS R21 AI128206NIDDK NIH HHS R01 DK115406NIGMS NIH HHS P20 GM113226NIH HHS K23AA021179NIH HHS P20GM113226NIH HHS P50AA024337NIH HHS R01AA021434NIH HHS R01AA023190NIH HHS R01AA023681NIH HHS R24AA025017-01NIH HHS U01AA021893-01NIH HHS U01AA021901NIH HHS U01AA022489-01A1U.S. Department of Veterans Affairs 1I01BX002996
Abstract
Alcoholic liver disease (ALD) is associated with gut dysbiosis and hepatic inflammasome activation. While it is known that antimicrobial peptides (AMPs) play a critical role in the regulation of bacterial homeostasis in ALD, the functional role of AMPs in the alcohol-induced inflammasome activation is unclear. The aim of this study was to determine the effects of cathelicidin-related antimicrobial peptide (CRAMP) on inflammasome activation in ALD. CRAMP knockout (Camp
Indexed as
AnimalsAntimicrobial Cationic PeptidesBiomarkersCathelicidinsDysbiosisHumansInflammasomesInterleukin-1betaLiverLiver Diseases, AlcoholicMaleMiceMice, KnockoutOxidative StressUric AcidAntimicrobial Cationic PeptidesBiomarkersCathelicidinsInflammasomesInterleukin-1betaUric AcidALDCRAMPIL‐1βLPSuric acid
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.