ReviewDer Nervenarzt2021
[The IMAGEN cohort: perspectives and problems of longitudinal research].
Review in Der Nervenarzt, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenetic risk factors for major mental disorders identified in psychiatric research show a substantial overlap. Therefore, it has been suggested that neurobiological research should focus on intermediate phenotypes that reflect shared aspects of different mental disorders due to overlapping genetic effects and environmental factors. Longitudinal studies are required to assess the interaction between genetic variability and modifying environmental factors and to investigate the effects on intermediate phenotypes and (mediated by them) on the expression of individual mental disorders.
objectiveDiscussion of the possibilities and limitations of longitudinal cohort studies using the IMAGEN study as an example. MATERIAL AND
methodsThe results of the European IMAGEN study are presented with a focus on addiction.
resultsThe longitudinal assessments of the IMAGEN cohort revealed that neuroimaging data indicating a low activation of the dopaminergic reinforcement system detected at the age of 14 years are predictive for increased drug use. In addition to genetic factors, environmental influences such as maternal smoking during pregnancy were correlated with this low activation.
conclusionLongitudinal neurobiological basic research can validate the effects of candidate genes and reveal relevant environmental factors. Relevant modifiable factors indicated by the IMAGEN study and related datasets include drug use during pregnancy, trauma and other experiences of violence, social disadvantage and exclusion.
Indexed as
Identifiers
33245403What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.