Evidence map›Paper›PMID 33245382›Full record

GuidelineDer Anaesthesist2021

Recommendations for treatment of critically ill patients with COVID-19 : Version 3 S1 guideline.

S Kluge, U Janssens, T Welte, S Weber-Carstens, G Schälte, B Salzberger, P Gastmeier, F Langer, M Welper, M Westhoff and 5 more

Open access · bronzeAbstract readPractice GuidelineReview
In one paragraph

Guideline in Der Anaesthesist, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 34 citations in OpenAlex.

  1. Longitudinal Evaluation of Lower Urinary Tract Symptoms up to Six Months after COVID-19 Infection in a Jordanian Cohort.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2025
    Article
  2. Review
  3. Intensive care unit admission criteria: a scoping review.Journal of the Intensive Care Society · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

S KlugeDeutsche Gesellschaft für Internistische Intensivmedizin und Notfallmedizin (DGIIN), Berlin, Germany. skluge@uke.de.
U JanssensDeutsche Gesellschaft für Internistische Intensivmedizin und Notfallmedizin (DGIIN), Berlin, Germany.
T WelteDeutsche Gesellschaft für Internistische Intensivmedizin und Notfallmedizin (DGIIN), Berlin, Germany.
S Weber-CarstensDeutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin (DIVI), Berlin, Germany.
G SchälteDeutsche Gesellschaft für Anästhesiologie und Intensivmedizin (DGAI), Nürnberg, Germany.
B SalzbergerDeutsche Gesellschaft für Infektiologie (DGI), Munich, Germany.
P GastmeierDeutsche Gesellschaft für Hygiene und Mikrobiologie (DGHM), Münster, Germany.
F LangerGesellschaft für Thrombose und Hämostaseforschung (GTH), Cologne, Germany.
M WelperDeutsche Gesellschaft für Anästhesiologie und Intensivmedizin (DGAI), Nürnberg, Germany.
M WesthoffDeutsche Gesellschaft für Pneumologie und Beatmungsmedizin (DGP), Berlin, Germany.
M PfeiferDeutsche Gesellschaft für Pneumologie und Beatmungsmedizin (DGP), Berlin, Germany.
F HoffmannDeutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin (DIVI), Berlin, Germany.
B W BöttigerDeutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin (DIVI), Berlin, Germany.
G MarxDeutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin (DIVI), Berlin, Germany.
C KaragiannidisDeutsche Gesellschaft für Internistische Intensivmedizin und Notfallmedizin (DGIIN), Berlin, Germany.
Deutsche Gesellschaft für Anästhesiologie und Intensivmedizin · DEDeutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin · DEGerman Respiratory Society · DEGerman Society of Medical Intensive Care and Emergency Medicine · DEAmbulatory Rehabilitation Center Berlin Adlershof · DEDeutsche Akademie für Kinder- und Jugendmedizin · DEDeutsche Gesellschaft für Information und Wissen · DEGesellschaft für Thrombose- und Hämostaseforschung · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since December 2019 a novel coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) has rapidly spread around the world resulting in an acute respiratory illness pandemic. The immense challenges for clinicians and hospitals as well as the strain on many healthcare systems has been unprecedented.The majority of patients present with mild symptoms of coronavirus disease 2019 (COVID-19); however, 5-8% become critically ill and require intensive care treatment. Acute hypoxemic respiratory failure with severe dyspnea and an increased respiratory rate (>30/min) usually leads to intensive care unit (ICU) admission. At this point bilateral pulmonary infiltrates are typically seen. Patients often develop a severe acute respiratory distress syndrome (ARDS).So far, remdesivir and dexamethasone have shown clinical effectiveness in severe COVID-19 in hospitalized patients. The main goal of supportive treatment is to ascertain adequate oxygenation. Invasive mechanical ventilation and repeated prone positioning are key elements in treating severely hypoxemic COVID-19 patients.Strict adherence to basic infection control measures (including hand hygiene) and correct use of personal protection equipment (PPE) are essential in the care of patients. Procedures that lead to formation of aerosols should be carried out with utmost precaution and preparation.

Indexed as

COVID-19Critical IllnessHumansSARS-CoV-2

Identifiers

PMID33245382
PMCPMC7694585
OpenAlexW3107516228

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.